B Cell Aplasia and Hypogammaglobulinemia after Carbamazepine Treatment

• Yamamoto Tatsuya

  Department of Neurology, Graduate School of Medicine, Chiba University

• Uchiyama Tomoyuki

  Department of Neurology, Graduate School of Medicine, Chiba University

• Takahashi Hirokatsu

  Department of Neurology, Graduate School of Medicine, Chiba University

• Himuro Keiichi

  Department of Neurology, Graduate School of Medicine, Chiba University

• Kanai Kazuaki

  Department of Neurology, Graduate School of Medicine, Chiba University

• Kuwabara Satoshi

  Department of Neurology, Graduate School of Medicine, Chiba University

抄録

Although immunosuppressive effects of antiepileptic drug are well known, serious complications of antiepileptic drug are rare. We report a case of hypogammaglobulinemia associated with aplasia of B lymphocytes after carbamazepine treatment. Despite repeated intravenous immunoglobulin replacement therapy, this condition persisted for more than three months. The present case suggested that routine monitoring of the blood cell count and serum levels of immunoglobulin are important in patients treated with carbamazepine, and a lymphocyte subpopulation study is valuable in cases of hypogammaglobulinemia.<br>

収録刊行物

• Internal Medicine

  Internal Medicine 49 (7), 707-708, 2010

  一般社団法人 日本内科学会

キーワード

• antiepileptic drug
• carbamazepine
• hypogammaglobulinemia
• B cell
• interstitial pneumonia

詳細情報

• CRID: 1390282679850210176
• NII論文ID: 130000251791
• DOI: 10.2169/internalmedicine.49.3087
• ISSN: 13497235
• ISSN: 09182918
• Web Site: http://www.jstage.jst.go.jp/article/internalmedicine/49/7/49_7_707/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010265570
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可