Meta-Analysis of Randomized Controlled Trials on the Treatment of Pulmonary Arterial Hypertension
-
- He Bing
- Department of Pediatrics, Renmin Hospital of Wuhan University
-
- Zhang Fengwen
- Department of Pediatrics, Peking University First Hospital
-
- Li Xueying
- Department of Statistics, Peking University First Hospital
-
- Tang Chaoshu
- Department of Physiology and Pathophysiology, Peking University Health Sciences Center Key Laboratory of Molecular Cardiology, Ministry of Education
-
- Lin Guosheng
- Department of Cardiology, Renmin Hospital of Wuhan University
-
- Du Junbao
- Department of Pediatrics, Peking University First Hospital
-
- Jin Hongfang
- Department of Pediatrics, Peking University First Hospital
書誌事項
- タイトル別名
-
- Meta-Analysis of Randomized Controlled Trials on Treatment of Pulmonary Arterial Hypertension
この論文をさがす
抄録
Background: The aim of the present meta-analysis was to evaluate the efficacy and safety of treating pulmonary arterial hypertension (PAH) with inhaled iloprost, oral bosentan and sildenafil. Methods and Results: The randomized controlled trials on the 3 drugs and placebo were retrieved from the databases MEDLINE, EMBASE, BIOSIS Previews and CNKI up to August 2009. In total 11 studies and 1,391 patients were selected. Compared with placebo, iloprost, bosentan and sildenafil reduced clinical worsening significantly (odds ratio [OR] =0.33, 95% confidence interval [CI] =0.22-0.49, P<0.00001), improved New York Heart Association/World Health Organization functional class (OR =2.81, 95%CI =1.95-4.03, P<0.00001), increased the 6-min walk test by 33.19 m, reduced systolic pulmonary arterial pressure, mean pulmonary arterial pressure and pulmonary vascular resistance, increased the cardiac index by 0.40 L · min-1 · m-2 and increased the cardiac output by 0.53 L/min. The incidence of serious adverse events was similar in the medication groups and the placebo group (OR =1.09, 95%CI =0.69-1.71, P=0.72). In terms of the clinical worsening and functional class amelioration, insignificant differences were found among iloprost, bosentan and sildenafil, but iloprost had the highest incidence of serious adverse events among the 3 drugs. Conclusions: Inhaled iloprost and oral bosentan and sildenafil are effective and safe in treating PAH. (Circ J 2010; 74: 74: 1458 - 1464)<br>
収録刊行物
-
- Circulation Journal
-
Circulation Journal 74 (7), 1458-1464, 2010
一般社団法人 日本循環器学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001205103308800
-
- NII論文ID
- 10026973601
- 10030695901
-
- NII書誌ID
- AA11591968
-
- COI
- 1:STN:280:DC%2BC3cnjsVOgug%3D%3D
-
- ISSN
- 13474820
- 13469843
-
- PubMed
- 20519876
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可