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- Duffels Mariëlle GJ
- Department of Cardiology, Academic Medical Center
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- Mulder Karlijn M
- Department of Cardiology, Academic Medical Center
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- Trip Mieke D
- Department of Cardiology, Academic Medical Center Department of Vascular Medicine, Academic Medical Center
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- de Groot Erik
- Department of Vascular Medicine, Academic Medical Center
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- Gort Johan
- Department of Vascular Medicine, Academic Medical Center
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- van Dijk Arie PJ
- Department of Cardiology, Radboud University Nijmegen Medical Center
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- Hoendermis Elke S
- Department of Cardiology, University Medical Center Groningen
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- Daliento Luciano
- Department of Cardiology, University of Padua
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- Zwinderman Aeiko H
- Department of Clinical Epidemiology and Biostatistics, Academic Medical Center
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- Berger Rolf MF
- Department of Paediatric Cardiology, University Medical Center Groningen
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- Mulder Barbara JM
- Department of Cardiology, Academic Medical Center Department of Cardiology, University Medical Center Utrecht
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Background: Cyanotic patients with congenital heart disease (CHD) might be protected against atherosclerosis. Methods and Results: Atherosclerotic risk factors and carotid intima - media thickness (IMT) were investigated in adults with cyanotic CHD and in unaffected age- and sex-matched controls. Fifty-four cyanotic patients (30 men, mean age 38, range 19-60 years) and 54 controls were included. Mean transcutaneous saturation of the cyanotic patients was 81±6%. Mean carotid IMT adjusted for age was significantly decreased in cyanotic patients compared to controls (0.55±0.1 mm vs 0.58±0.08 mm: ΔIMT =0.04 mm [SE 0.015], P=0.01). In cyanotic patients lower total cholesterol levels were observed (4.4±1 mmol/L vs 4.9±1 mmol/L; P=0.02), as well as lower thrombocyte levels (173±81×109 /L vs 255±54×109 /L; P<0.01), higher bilirubin levels (18.6±11 μmol/L vs 12.7±6 μmol/L; P<0.01), and lower diastolic and systolic blood pressure (71±9 mmHg vs 76±9 mmHg, P<0.01; 113±14 mmHg vs 124±12 mmHg, P<0.01, respectively). Conclusions: In patients with cyanotic CHD carotid IMT, and hence atherosclerosis disease risk, was decreased. This might be due to a combination of reduced atherosclerotic risk factors such as lower blood pressure, lower total cholesterol levels, higher bilirubin levels and lower thrombocyte levels. (Circ J 2010; 74: 1436 - 1441)<br>
収録刊行物
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- Circulation Journal
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Circulation Journal 74 (7), 1436-1441, 2010
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390001205103313792
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- NII論文ID
- 10030695791
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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- 使用不可