Keratoconus in a Cynomolgus Monkey

• Kodama Rinya

  Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd.

• Yang Xiuying

  Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd.

• Araki Tomoaki

  Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd.

• Sato Masato

  Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd.

• Iwashige Shuichiro

  Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd.

• Tanigawa Yohei

  Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd.

• Uchimura Mie

  Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd.

• Ishimaru Keisuke

  Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd.

• Sasaki Yuji

  Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd.

• Kamimura Yasuhiro

  Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd.

• Maeda Hiroshi

  Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd.

抄録

In a seven-year-old male cynomolgus monkey, erythema of the upper eyelid and forehead and corneal opacity, edema and conical protrusion in the eye were observed. At necropsy, ophthalmological and serological examinations revealed binocular corneal opacity and conical protrusion and a high IgE level, respectively. Thinning of the epithelium and stroma of the cornea were noted histopathologically. At the center of the corneal epithelium, the number of epithelial cells was reduced, their cytoplasm was poorer and the basal cells were flatter than at the periphery. Bowman's membrane was folded with partial loss or breakage. Collagen fibers were compacted or disarranged, and the keratocytes were increased in the stroma, with focal pyknosis or loss of the endothelium and folding of Descemet's membrane. Electron microscopical examination revealed atrophy of the corneal epithelial basal cells. This is the first report of a case of keratoconus in a cynomolgus monkey. <br>

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃ　Ｐａｔｈｏｌｏｇｙ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃ　Ｐａｔｈｏｌｏｇｙ 23 (1), 53-58, 2010

  日本毒性病理学会

キーワード

• keratoconus
• high serum IgE
• atopy-like mechanism
• cynomolgus monkey

詳細情報

• CRID: 1390282679393185664
• NII論文ID: 130000262643
• NII書誌ID: AN10232280
• DOI: 10.1293/tox.23.53
• ISSN: 1881915X
• ISSN: 09149198
• NDL書誌ID: 10647718
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10647718
• Web Site: http://www.jstage.jst.go.jp/article/tox/23/1/23_1_53/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010265329
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可