Anatomy: Immunohistochemical localization of aquaporin-4 in the rat pituitary gland

• KUWAHARA Sachi

  Department of Anatomy and Cell Biology, Hyogo College of Medicine

• MAEDA Seishi

  Department of Anatomy and Cell Biology, Hyogo College of Medicine

• ARDILES Yona

  Department of Anatomy and Cell Biology, Hyogo College of Medicine

• JUN Jin Gon

  Department of Anatomy and Cell Biology, Hyogo College of Medicine

• TANAKA Koichi

  Department of Anatomy and Cell Biology, Hyogo College of Medicine

• HAYAKAWA Tetsu

  Department of Anatomy and Cell Biology, Hyogo College of Medicine

• SEKI Makoto

  Department of Anatomy and Cell Biology, Hyogo College of Medicine

書誌事項

タイトル別名

• Immunohistochemical Localization of Aquaporin-4 in the Rat Pituitary Gland

抄録

Aquaporin-4 (AQP4) is an isoform of membrane water channel aquaporins. It is most abundant in the brain, and is believed to be expressed by astrocytes and ependymal cells. We have reported previously that rat pituitary glands express some aquaporin subtypes, including AQP4, but the precise distribution of AQP4 in the pituitary gland is not known. The present work investigated whether AQP4 immunoreactivity exists in various pituitary cell types in adult rats, using double immunofluorescent staining and confocal microscopy. In the adenohypophysis, co-labeling for S-100 protein indicated that folliculo-stellate (FS) cells and marginal layer cells in Rathke's residual pouch have extensive labeling for AQP4. Some AQP4-expressing cells also contained glial fibrillary acidic protein (GFAP) in parenchymal tissue of the anterior lobe, and cytokeratin in marginal layer cells. AQP4 was not coexpressed in any hormone-producing pituitary cells, however. In the neurohypophysis, AQP4 was expressed in some pituicytes, which have been identified as GFAP-positive. These results suggest that AQP4, which is expressed in FS cells, in marginal layer cells and in pituicytes, but not in hormone-producing cells, is important in water transfer within the pituitary gland; astrocytes and ependymal cells do the same in the brain.<br>

収録刊行物

• Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ

  Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ 72 (10), 1307-1312, 2010

  公益社団法人 日本獣医学会

キーワード

• aquaporin-4
• folliculo-stellate cell
• immunofluorescence analysis
• pituicyte
• pituitary gland

詳細情報

• CRID: 1390282681405389312
• NII論文ID: 130000264197
• NII書誌ID: AA10796138
• DOI: 10.1292/jvms.10-0087
• ISSN: 13477439
• ISSN: 09167250
• NDL書誌ID: 10878883
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10878883
• Web Site: http://www.jstage.jst.go.jp/article/jvms/72/10/72_10-0087/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2011120954
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可