Clinical pathology: Peripheral blood CD4 and CD8 double-positive T cells of rhesus macaques become vulnerable to simian immunodeficiency virus by in vitro stimulation due to the induction of CCR5

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  • MATSUMOTO Yusuke
    Department of Veterinary Microbiology, University of Miyazaki
  • MIURA Tomoyuki
    Laboratory of Primate Model, Experimental Research Center for Infectious Disease, Institute for Virus Research, Kyoto University
  • AKARI Hirofumi
    Tsukuba Primate Research Center, National Institute of Biomedical Innovation
  • GOTO Yoshitaka
    Department of Veterinary Microbiology, University of Miyazaki
  • HAGA Takeshi
    Department of Veterinary Microbiology, University of Miyazaki

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  • Peripheral Blood CD4 and CD8 Double-Positive T Cells of Rhesus Macaques Become Vulnerable to Simian Immunodeficiency Virus by In Vitro Stimulation Due to the Induction of CCR5

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In vivo Simian Immunodeficiency Virus (SIV) challenge of macaques demonstrated the earlier disappearance of CD4 and CD8 double-positive (DP) T cells than CD4 single-positive T cells, although its mechanism remains unclear. Here we found that peripheral DP T cells were readily induced to express CCR5, a secondary receptor for SIV, by in vitro stimulation with either concanavalin A or anti-CD3/CD28 monoclonal antibodies. Activated DP T cells were more vulnerable to SIV infection, indicating that the ability of DP T cells to readily express CCR5 after activation may hasten DP T cell death by SIV infection in vivo.<br>

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