Subclinical Hypercortisolism among Polycythemia Vera Patients

DOI Web Site 参考文献23件
  • Bilgir Oktay
    Department of Internal Medicine, Division of Hematology, Izmir Bozyaka Training and Research Hospital
  • Kebapcilar Levent
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Izmir Bozyaka Training and Research Hospital
  • Alacacioglu Inci
    Department of Internal Medicine, Division of Hematology, Izmir Ataturk Training and Research Hospital
  • Bilgir Ferda
    Department of Internal Medicine, Division of Izmir Bozyaka Training and Research Hospital
  • Yildiz Yasar
    Department of Internal Medicine, Division of Izmir Bozyaka Training and Research Hospital
  • Yuksel Arif
    Department of Internal Medicine, Division of Izmir Bozyaka Training and Research Hospital
  • Sari Ismail
    Department of Internal Medicine, Division of Izmir Bozyaka Training and Research Hospital

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Background JAK2V617F, a somatic gain-of-function mutation involving the JAK2 tyrosine kinase gene, occurs in nearly all patients with polycythemia vera (PV). JAK2 is also essential in hypothalamo-pituitary-adrenal (HPA) axis system which is known to play a role in subsequent steroid secretion. The purpose of this study was to determine whether or not PV induces subclinical hypercortisolism (SH).<br> Design Cross-sectional study. In order to compare the prevalence of SH in PV and matched control individuals, we performed a case-controlled study, enrolling 31 PV and 20 age- and body mass index-matched patients.<br> Methods and Results Adrenal endocrine function was assessed in a cohort of 31 patients with PV. Baseline serum cortisol levels and 2-day 2 mg DST (dexamethasone suppression test, 0.5 mg dexamethasone orally every 6 hours for two days) showed a trend for higher serum cortisol levels in PV patients than in control subjects. Among the 31 patients, 6 had biological abnormality of the hypothalamic-pituitary-adrenal axis and were diagnosed as subclinical hypercortisolism. None of the subjects in the control group exhibited cortisol responses to DST higher than 50 nmol/L.<br> Discussion In conclusion, a relatively high prevalence of hypercortisolism was found in PV patients. As these observations were in a small cohort of PV, further studies are needed to evaluate HPA axis in PV patients.<br>

収録刊行物

  • Internal Medicine

    Internal Medicine 49 (13), 1277-1280, 2010

    一般社団法人 日本内科学会

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