Effect of Particle Size on Skin Permeation and Retention of Piroxicam in Aqueous Suspension
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- Moribe Kunikazu
- Graduate School of Pharmaceutical Sciences, Chiba University
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- Shibata Mizuho
- Graduate School of Pharmaceutical Sciences, Chiba University
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- Furuishi Takayuki
- Research Unit of Pharmaceutics, School of Pharmacy, Nihon University
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- Higashi Kenjirou
- Graduate School of Pharmaceutical Sciences, Chiba University
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- Tomono Kazuo
- Research Unit of Pharmaceutics, School of Pharmacy, Nihon University
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- Yamamoto Keiji
- Graduate School of Pharmaceutical Sciences, Chiba University
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Abstract
The effects of particle size on the skin permeation and retention of piroxicam (PXC) in an aqueous suspension were investigated. PXC particles of about 23 nm, 173 nm, and 2.1 μm in size were prepared by the cogrinding of PXC/polyvinylpyrrolidone (PVP) K12/sodium dodecyl sulfate physical mixture (mean particle size, 9.6 μm) using a vibrational rod and ball mills. Particles were stable after storage in 0.1 m acetate buffer (pH 4.5) for 24 h. The amount of PXC that permeated and was retained in hairless mouse skin increased with the reduction of particle size up to 23 nm. Amorphous PXC was formed when PXC was coground with PVP, though the amorphous formation did not affect the amount of PXC permeated. Reduction of particle size to less than 50 nm, and the subsequent increase in surface area of PXC nanocrystals appeared to affect skin permeation and retention behavior.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 58 (8), 1096-1099, 2010
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282679149597440
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- NII Article ID
- 130000299822
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 10764235
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed