Steamed Ginseng-Leaf Components Enhance Cytotoxic Effects on Human Leukemia HL-60 Cells

    • Minh Chau Van
    • Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology
    • Kiem Phan Van
    • Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology
    • Boo Hye-Jin
    • Department of Pharmacology, School of Medicine, Institute of Medical Sciences, Jeju National University
    • Kang Hee-Kyoung
    • Department of Pharmacology, School of Medicine, Institute of Medical Sciences, Jeju National University

Abstract

Three new dammarane-type glycosides, named ginsenosides SL1—SL3 (1—3), and eleven known compounds (4—14) were isolated from the heat-processed leaves of Panax ginseng. Their structures were elucidated on the basis of extensive chemical and spectroscopic methods. Cytotoxic-activity testing of compounds 1—14 against human leukemia HL-60 cells showed that ginsenosides Rh3 (11) and Rk2 (12) exhibited potent effects with IC50 values of 0.8 and 0.9 μM. In addition, ginsenosides SL3 (3), 20S-Rg2 (7), F4 (10), 20S-Rh2 (13) displayed strong activity with IC50 values of 9.0, 9.0, 7.5, and 8.2 μM, respectively. This is the first report on chemical components of the steamed ginseng leaves.

Journal

Chemical and Pharmaceutical Bulletin  

Chemical and Pharmaceutical Bulletin 58(8), 1111-1115, 2010 

The Pharmaceutical Society of Japan

Codes

  • NII Article ID (NAID) :
    130000299826
  • NII NACSIS-CAT ID (NCID) :
    AA00602100
  • Text Lang :
    EN
  • ISSN :
    0009-2363
  • NDL Article ID :
    10764309
  • NDL Source Classification :
    ZS51(科学技術--薬学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No. :
    Z53-D167
  • DOI :
    10.1248/cpb.58.1111
  • Databases :
    NDL  J-STAGE 

Share