VAMP2 Marks Quiescent Satellite Cells and Myotubes, but not Activated Myoblasts

DOI Web Site 被引用文献5件 参考文献16件
  • Tajika Yuki
    Department of Anatomy, Gunma University Graduate School of Medicine
  • Takahashi Maiko
    Department of Anatomy, Gunma University Graduate School of Medicine
  • Hino Mizuki
    Department of Anatomy, Gunma University Graduate School of Medicine
  • Murakami Tohru
    Department of Anatomy, Gunma University Graduate School of Medicine
  • Yorifuji Hiroshi
    Department of Anatomy, Gunma University Graduate School of Medicine

この論文をさがす

抄録

We examined the expression and intracellular localization of vesicle-associated membrane protein 2 (VAMP2) during the differentiation of skeletal muscle cells by immunofluorescence microscopy. In isolated single myofibers, VAMP2 was expressed in quiescent satellite cells, downregulated in proliferating myoblastic cells, and re-expressed with differentiation. In the myoblastic cell line C2C12, VAMP2 was expressed at a low level in the proliferating stage, and then increased after differentiation into myotubes. Based on these results, we propose that VAMP2 can be used as a molecular marker for both quiescent satellite cells and myotubes, but not for proliferating myoblasts. We also found the partial colocalization of VAMP2 with transferrin- or Rab11-labeled vesicles in myotubes, suggesting a role of VAMP2 in the trafficking of recycling endosomes.<br>

収録刊行物

被引用文献 (5)*注記

もっと見る

参考文献 (16)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ