Presence of Circadian oscillation of Multidrug Resistance Gene 1 in KB-C2 cell line

DOI Web Site 参考文献20件
  • Sassa Motoki
    Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
  • Koyama Yoshihisa
    Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
  • Higashimoto Masashi
    Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
  • Ono Koichiro
    Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
  • Yoshimoto Nobuhiro
    Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
  • Momma Tomoyuki
    Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
  • Saito Masaru
    Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
  • Ando Jin
    Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
  • Noda Masaru
    Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
  • Miyamoto Kotaro
    Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
  • Kobayashi Yusuke
    Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
  • Sugeno Hidekazu
    Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
  • Ishigame Teruhide
    Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
  • Fujita Shotaro
    Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
  • Ito Testuro
    Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
  • Sakamoto Wataru
    Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
  • Abe Noriko
    Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
  • Iwadate Manabu
    Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
  • Yoshida Tuneyuki
    Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
  • Ohshima Takasi
    Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
  • Takebayashi Yuji
    Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
  • Takenoshita Seiichi
    Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine

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Many physiological, biochemical and behavioral processes are under circadian regulation, which is generated by an internal time-keeping mechanism referred to as biological clock in almost all organisms from bacteria to mammals. Although the substantial evidences that the circadian clock could modulate the morbidity and efficacy of anticancer therapy have been proposed, underlying mechanisms for chronotherapy has been only poorly elucidated, and it has not been popular in clinic. The aim of this study was to determine the relationship between the expression of P-glycoprotein (P-gp)/MDR1, which is one of the important molecules in anti-cancer drug resistance, and circadian rhythm in KB-C2 cells. The present study demonstrated that both MDR1 expression level and its promoter activity oscillated after treatment with high concentration of fetal bovine serum. Moreover, cytotoxic effect of taxol were dependent on the fluctuated levels of MDR1. These results suggest that the circadian rhythm of MDR1 may have an influential effect on cytotoxicity of anti-cancer drug and could be available for chemotherapy in clinic.

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