Internal medicine: Prekallikrein deficiency in a dog

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  • OKAWA Takumi
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University
  • YANASE Takuma
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University
  • SHIMOKAWA MIYAMA Takako
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University
  • HIRAOKA Hiroko
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University
  • BABA Kenji
    Laboratory of Veterinary Parasitology, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University
  • TANI Kenji
    Laboratory of Veterinary Surgery, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University
  • OKUDA Masaru
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University
  • MIZUNO Takuya
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University

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  • Prekallikrein Deficiency in a Dog

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Prekallikrein (PK) deficiency is an uncommon disorder in dogs. In this report, we describe a case of a dog that was referred for neurological defects and had a prolonged activated partial thromboplastin time (aPTT) and normal prothrombin time (PT) with no hemostatic defects. By using human PK-deficient plasma, the dog was diagnosed to have PK deficiency. The nucleotide sequence of normal canine PK cDNA was determined and compared with the genomic sequences of PK in the affected dog. The comparison revealed that the dog had a point mutation in exon 8 that leads to an amino acid substitution in the fourth apple domain of PK. This is the first report showing a point mutation of PK in a dog with PK deficiency.<br>

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