Anticholinesterase and Antioxidant Constituents from Gloiopeltis furcata

• Fang Zhe

  College of Pharmacy, Catholic University of Daegu

• Jeong Su Yang

  College of Pharmacy, Catholic University of Daegu

• Jung Hyun Ah

  Division of Food Science and Biotechnology, Pukyong National University

• Choi Jae Sue

  Division of Food Science and Biotechnology, Pukyong National University

• Min Byung Sun

  College of Pharmacy, Catholic University of Daegu

• Woo Mi Hee

  College of Pharmacy, Catholic University of Daegu

抄録

Activity-directed isolation of the ethyl acetate, methylene chloride and n-hexane fractions of Gloiopeltis furcata resulted in the isolation of 18 compounds. Their structures were elucidated as 2-(3-hydroxy-5-oxotetrahydrofuran-3-yl)acetic acid (1), glutaric acid (2), succinic acid (3), nicotinic acid (4), (E)-4-hydroxyhex-2-enoic acid (5), cholesterol (6), 7-hydroxycholesterol (7), uridine (8), glycerol (9), 5-(hydroxymethyl)-2-methoxybenzene-1,3-diol (10), (5E,7E)-9-oxodeca-5,7-dienoic acid (11), (Z)-3-ethylidene-4-methylpyrrolidine-2,5-dione (12), dehydrovomifoliol (13), loliolide (14), cholesteryl stearate (15), palmitic acid (16), cis-5,8,11,14,17-eicosapentaenoic acid (17) and α-linolenic acid (18) on the basis of spectroscopic and chemical evidences. Their anticholinesterase and antioxidant activities were evaluated via inhibitory activities on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) as well as scavenging activities on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and peroxynitrite (ONOO⁻). All isolated compounds (1—18) exhibited moderate AChE inhibitory activities with IC₅₀ values ranging from 1.14—12.50 μg/ml, whereas 1, 7, 9, 17, and 18 showed mild BChE inhibitory activities with IC₅₀ values ranging from 5.57—15.89 μg/ml. Although most of the compounds isolated were lacking the scavenging activity on DPPH radical and ONOO⁻, 5 and 10 showed good DPPH radical scavenging activity, and 5, 10, and 16 showed potent ONOO⁻ scavenging activity.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 58 (9), 1236-1239, 2010

  公益社団法人 日本薬学会

キーワード

• <i>Gloiopeltis furcata</i>
• antioxidant activity
• cholinesterase inhibition
• 2-(3-hydroxy-5-oxotetrahydrofuran-3-yl)acetic acid
• (5<i>E</i>,7<i>E</i>)-9-oxodeca-5,7-dienoic acid

詳細情報

• CRID: 1390001204172950528
• NII論文ID: 130000324602
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.58.1236
• ISSN: 13475223
• ISSN: 00092363
• NDL書誌ID: 10796490
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10796490
• Web Site: http://www.jstage.jst.go.jp/article/cpb/58/9/58_9_1236/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2011175582
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
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