A Case of Lymphomatoid Granulomatosis-Like Lung Lesions with Abundant Infiltrating IgG4-Positive Plasma Cells Whose Serum IgG4 Levels Became High Following the Start of Corticosteroid Therapy
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- Miyashita Tomoko
- Department of Internal Medicine, Osaka City General Hospital
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- Yoshioka Katsunobu
- Department of Internal Medicine, Osaka City General Hospital
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- Nakamura Tomoyuki
- Department of Internal Medicine, Osaka City General Hospital
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- Kubo Yuki
- Department of Pathology, Osaka City General Hospital
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- Inoue Takeshi
- Department of Pathology, Osaka City General Hospital
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- Morikawa Takashi
- Department of Nephrology and Hypertension, Osaka City General Hospital
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- Ishii Keiichi
- Department of Urology, Osaka City General Hospital
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- Yamagami Keiko
- Department of Internal Medicine, Osaka City General Hospital
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A 59-year-old man with a history of prostate hyperplasia was admitted to our hospital for further examination of a lung mass and renal dysfunction. Lung biopsy specimens revealed that inflammatory cells had infiltrated into the blood vessel walls. We initially suspected lymphomatoid granulomatosis, but Epstein Barr virus-encoded small RNA was negative. However, 50% of the infiltrating plasma cells were positive for IgG4. Furthermore, the kidneys and prostate contained abundant IgG4-positive plasma cells. He was diagnosed with IgG4-related sclerosing disease even though serum IgG4 levels were not elevated (45.7 mg/dL). Prednisolone reduced the lung masses and ameliorated renal function, but the serum IgG4 level increased (377 mg/dL). Seronegative IgG4-related sclerosing disease should be considered when patients present with such symptoms and treatment responses, and the secretion of IgG4 might be blocked by its active synthesis.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 49 (18), 2007-2011, 2010
一般社団法人 日本内科学会
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詳細情報 詳細情報について
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- CRID
- 1390001204870421632
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- NII論文ID
- 130000336893
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- ISSN
- 13497235
- 09182918
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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- 抄録ライセンスフラグ
- 使用不可