A Vesicular Transporter That Mediates Aspartate and Glutamate Neurotransmission

• Miyaji Takaaki

  Department of Genomics and Proteomics, Advanced Science Research Center, Okayama University

• Omote Hiroshi

  Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Moriyama Yoshinori

  Department of Genomics and Proteomics, Advanced Science Research Center, Okayama University Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

抄録

Aspartate, an excitatory amino acid, is known to be stored in synaptic vesicles and exocytosed from some neurons to perform aspartergic neurotransmission. Through in vitro reconstitution, we found that sialin, a lysosomal sialic acid exporter, is responsible for the vesicular storage of aspartate in hippocampal neurons and pinealocytes. Mutations found in Salla disease cause decreased aspartate transport activity without affecting sialic acid transport. Thus, sialin is a multifunctional transporter. It is possible that people with Salla disease lose the ability of aspartergic neurotransmission, and this could explain why Salla disease involves severe neurological defects.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 33 (11), 1783-1785, 2010

  公益社団法人 日本薬学会

キーワード

• aspartate
• neurotransmission
• Salla disease
• vesicular excitatory amino acid transporter
• veicular glutamate transporter

詳細情報

• CRID: 1390001204624744320
• NII論文ID: 130000402295
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.33.1783
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 10858999
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10858999
• Web Site: http://www.jstage.jst.go.jp/article/bpb/33/11/33_11_1783/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2011206175
• 本文言語コード: en
• データソース種別:
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