The Antioxidative and Antilipidemic Effects of Different Molecular Weight Chitosans in Metabolic Syndrome Model Rats

• Anraku Makoto

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• Michihara Akihiro

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• Yasufuku Taira

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• Akasaki Kenji

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• Tsuchiya Daiju

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• Nishio Hiroaki

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• Maruyama Toru

  Graduate School of Pharmaceutical Sciences, Kumamoto University

• Otagiri Masaki

  Graduate School of Pharmaceutical Sciences, Kumamoto University Faculty of Pharmaceutical Sciences, Sojo University

• Maezaki Yuji

  Nippon Kayaku Food Techno Co., Ltd.

• Kondo Yuko

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• Tomida Hisao

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

抄録

The effect of high and low molecular weight chitosans (HMC; 1000 kDa, LMC; 30 kDa) on oxidative stress and hypercholesterolemia was investigated using male 6-week-old Wistar Kyoto rats as a normal model (Normal-rats) and spontaneously hypertensive rat/ND mcr-cp (SHP/ND) as a metabolic syndrome model (MS-rats), respectively. In Normal-rats, the ingestion of both chitosans over a 4 week period resulted in a significant decrease in total body weight (BW), glucose (Gl), triglyceride (TG), low density lipoprotein (LDL) and serum creatinine (Cre) levels. The ingestion of both chitosans also resulted in a lowered ratio of oxidized to reduced albumin and an increase in total plasma antioxidant activity. In addition to similar results in Normal-rats, the ingestion of only HMC over a 4 week period resulted in a significant decrease in total cholesterol levels in MS-rats. Further, the ingestion of LMC resulted in a significantly higher antioxidant activity than was observed for HMC in both rat models. In in vitro studies, LMC caused a significantly higher reduction in the levels of two stable radicals, compared to HMC, and the effect was both dose- and time-dependent. The findings also show that LDL showed strong binding in the case of HMC. These results suggest that LMC has a high antioxidant activity as well as antilipidemic effects, while HMC results in a significant reduction in the levels of pro-oxidants such as LDL in the gastrointestinal tract, thereby inhibiting the subsequent development of oxidative stress in the systemic circulation in metabolic model rats.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 33 (12), 1994-1998, 2010

  公益社団法人 日本薬学会

キーワード

• metabolic syndrome
• chitosan
• antilipidemic effect
• antioxidant activity

詳細情報

• CRID: 1390282679605271808
• NII論文ID: 130000402332
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.33.1994
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 10894577
• Web Site: http://id.ndl.go.jp/bib/10894577
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10894577
• Web Site: http://www.jstage.jst.go.jp/article/bpb/33/12/33_12_1994/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2011238669
• 本文言語コード: en
• データソース種別:
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