The utility of poly(γ-glutamic acid) nanoparticles as antigen delivery carriers in dendritic cell-based cancer immunotherapy

• Matsuo Keisuke

  Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University

• Ishii Yumiko

  Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University

• Matsuo Kazuhiko

  Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University

• Yoshinaga Tomoyo

  Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University

• Akashi Mitsuru

  The Center for Advanced Medical Engineering and Informatics, Osaka University Department of Applied Chemistry, Graduate School of Engineering, Osaka University

• Mukai Yohei

  Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University

• Yoshioka Yasuo

  Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University The Center for Advanced Medical Engineering and Informatics, Osaka University

• Okada Naoki

  Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University

• Nakagawa Shinsaku

  Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University The Center for Advanced Medical Engineering and Informatics, Osaka University

書誌事項

タイトル別名

• The Utility of Poly(.GAMMA.-glutamic acid) Nanoparticles as Antigen Delivery Carriers in Dendritic Cell-Based Cancer Immunotherapy
• The utility of poly g glutamic acid nanoparticles as antigen delivery carriers in dendritic cell based cancer immunotherapy

抄録

Cytotoxic T-lymphocytes (CTLs) specific for tumor-associated antigens (TAAs) act in the immune surveillance system as major effector cells to eliminate malignant cells. Immunization with TAA-loaded dendritic cells (DCs) has great potential for treating cancer, because DCs are potent antigen-presenting cells capable of inducing antigen-specific CTLs by the primary activation of naive T-lymphocytes. The establishment of a non-cytotoxic and efficient antigen delivery method is required to improve the efficacy of DC-based cancer immunotherapy. We developed biodegradable poly(γ-glutamic acid) nanoparticles (γ-PGA NPs) that can efficiently entrap various proteins as antigen delivery carriers. γ-PGA NPs efficiently delivered entrapped antigenic proteins into DCs without cytotoxicity and presented antigens to DCs via major histocompatibility complex class I and II molecules. Immunization with TAA-loaded DCs using γ-PGA NPs inhibited tumor growth by inducing TAA-specific CTLs. These findings indicate that γ-PGA NPs can function as useful antigen delivery carriers in DC-based cancer immunotherapy.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 33 (12), 2003-2007, 2010

  公益社団法人 日本薬学会

キーワード

• poly(γ-glutamic acid) nanoparticle
• antigen delivery carrier
• dendritic cell

詳細情報

• CRID: 1390282679605279360
• NII論文ID: 130000402334
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.33.2003
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 10894603
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10894603
• Web Site: http://www.jstage.jst.go.jp/article/bpb/33/12/33_12_2003/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可