Floating and Sustained-Release Characteristics of Effervescent Tablets Prepared with a Mixed Matrix of Eudragit L-100-55 and Eudragit E PO
-
- Bani-Jaber Ahmad Khaled
- Faculty of Pharmacy, The University of Jordan
-
- Alkawareek Mahmoud Yousef
- Faculty of Pharmacy, The University of Jordan
-
- Al-Gousous Jozef Jawad
- Faculty of Pharmacy, The University of Jordan
-
- Abu Helwa Ahmad Yousef
- Faculty of Pharmacy, The University of Jordan
この論文をさがす
抄録
The aim of this study was to evaluate the influence of Na-bicarbonate as an effervescent agent on the floating and sustained-release characteristics in 0.1 M HCl of tablets made of Eudragit E PO (EE) and/or Eudragit L-100-55 (EL) as matrix formers at different EE : EL weight ratios: 0 : 100, 25 : 75, 50 : 50, 75 : 25, and 100 : 0. The tablets were made by direct compression utilizing metronidazole as a model drug. Effervescent tablets with 50EE/50EL (w/w) showed the best floating and sustained drug release properties in the dissolution medium. The corresponding noneffervescent tablets were nonfloating and showed significantly faster drug release. Effervescent tablets with single polymers showed an immediate drug release pattern. These results were explained by Fourier-transform infrared spectroscopy and elemental analysis, which showed strong evidence of interpolyelectrolyte complexation between EE and EL when they were exposed to 0.1 M HCl as an effervescent hybrid matrix, but not as a noneffervescent hybrid matrix. The role of Na-bicarbonate in allowing EE–EL complexation during dissolution was explained as due to raising the pH around EL particles for sufficient polymer ionization and ionic-interaction with the ionized EE.
収録刊行物
-
- CHEMICAL & PHARMACEUTICAL BULLETIN
-
CHEMICAL & PHARMACEUTICAL BULLETIN 59 (2), 155-160, 2011
公益社団法人 日本薬学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282679149871360
-
- NII論文ID
- 130000405508
-
- NII書誌ID
- AA00602100
-
- ISSN
- 13475223
- 00092363
-
- NDL書誌ID
- 10951811
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可