Isolation of Salsolinol, a Tetrahydroisoquinoline Alkaloid, from the Marine Sponge Xestospongia cf. vansoesti as a Proteasome Inhibitor

• Nagasawa Yumiko

  Graduate School of Pharmaceutical Sciences, Kumamoto University

• Ueoka Reiko

  Graduate School of Pharmaceutical Sciences, Kumamoto University

• Yamanokuchi Rumi

  Graduate School of Pharmaceutical Sciences, Kumamoto University

• Horiuchi Naoki

  Graduate School of Science, Chiba University

• Ikeda Tsuyoshi

  Graduate School of Pharmaceutical Sciences, Kumamoto University

• Rotinsulu Henki

  Faculty of Agriculture, Universitas Pembangunan Indonesia Tohoku Pharmaceutical University

• Mangindaan Remy E. P.

  Faculty of Fisheries and Marine Science, Sam Ratulangi University

• Ukai Kazuyo

  Tohoku Pharmaceutical University

• Kobayashi Hisayoshi

  Institute of Molecular and Cellular Biosciences, University of Tokyo

• Namikoshi Michio

  Tohoku Pharmaceutical University

• Hirota Hiroshi

  RIKEN Genomic Sciences Center

• Yokosawa Hideyoshi

  School of Pharmacy, Aichi Gakuin University

• Tsukamoto Sachiko

  Graduate School of Pharmaceutical Sciences, Kumamoto University Graduate School of Science, Chiba University

Abstract

Salsolinol (1), a tetrahydroisoquinoline alkaloid, was isolated from the marine sponge Xestospongia cf. vansoesti collected in Indonesia as a proteasome inhibitor, along with three salsolinol derivatives, norsalsolinol (2), cis-4-hydroxysalsolinol (3), and trans-4-hydroxysalsolinol (4). Compounds 1 and 2 inhibited the chymotrypsin-like activity of the proteasome with IC₅₀ values of 50 and 32 μg/ml, respectively, but 3 and 4 showed no inhibitory effect even at 100 μg/ml.

Journal

• Chemical and Pharmaceutical Bulletin

  Chemical and Pharmaceutical Bulletin 59 (2), 287-290, 2011

  The Pharmaceutical Society of Japan

Keywords

• tetrahydroisoquinoline alkaloid
• proteasome
• chymotrypsin-like activity
• marine sponge

Details

• CRID: 1390001204173112448
• NII Article ID: 130000405530
• NII Book ID: AA00602100
• DOI: 10.1248/cpb.59.287
• ISSN: 13475223
• ISSN: 00092363
• HANDLE: 2298/00043555
• NDL BIB ID: 10951962
• Web Site: https://kumadai.repo.nii.ac.jp/records/31932
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10951962
• Web Site: http://www.jstage.jst.go.jp/article/cpb/59/2/59_2_287/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2011335823
• Text Lang: en
• Data Source:
  • JaLC
  • IRDB
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed