Synthesis of New 1,2,4-Triazole[3,4-b][1,3,4]thiadiazoles Bearing Pyrazole as Potent Antimicrobial Agents
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- Sanjeeva Reddy Cherkupally
- Department of Chemistry, Kakatiya University
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- Sanjeeva Rao Lade
- Department of Chemistry, Kakatiya University
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- Rajesh Kumar Gaddam
- Department of Chemistry, Kakatiya University
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- Nagaraj Adki
- Department of Pharmaceutical Chemistry, Telangana University
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A new series of 6-(aryl/heteryl)-3-(5-methyl-1-phenyl-1H-4-pyrazolyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles (7a—j) has been synthesized by the reaction of 4-amino-5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-4H-1,2,4-triazol-3-yl-hydrosulfide (6) with POCl3 and the corresponding aryl/heteryl carboxylic acid, in ethanol at reflux temperature for 12 h. All the synthesized compounds were tested for in vitro activities against certain strains of bacteria such as Staphylococcus aureus, Bacillus subtilis, Escherichia coli and fungi such as Aspergillus niger, Aspergillus nodulans, Alternaria alternate. Compounds having 4-chlorophenyl (7d), 4-aminophenyl (7f), 4-nitrophenyl (7h) and 3-pyridyl (7i) substituents at 6-position of thiadiazole ring, showed marked inhibition of bacterial and fungal growth nearly equal to the standards. The other new compounds also showed appreciable activity against the test bacteria and fungi.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 58 (10), 1328-1331, 2010
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679149384960
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- NII論文ID
- 130000405635
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 10825157
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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