Systematic Phytochemical Investigation of Abies spectabilis

• Wu Liang

  Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University College of Science, Northwest Agriculture & Forestry University

• Li Yong-Li

  Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University

• Li Su-Mei

  Key Laboratory of Marine Bio-resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, and RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences

• Yang Xian-Wen

  Key Laboratory of Marine Bio-resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, and RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences

• Xia Jia-Han

  Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University

• Zhou Le

  College of Science, Northwest Agriculture & Forestry University

• Zhang Wei-Dong

  Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University

抄録

Systematical phytochemical investigations on Abies spectabilis afforded 72 chemical constituents. On the basis of physical and spectroscopic data, including 1D and 2D homo- and heteronuclear NMR experiments (heteronuclear single quantum coherence (HSQC), ¹H–¹H correlation spectroscopy (COSY), heteronuclear multiple bond connectivity (HMBC), and nuclear Overhauser effect spectroscopy (NOESY)), and by comparison with the literature references, they were identified as 3 triterpenoids, 23 diterpenoids, 1 sesquiterpenoid, 13 flavonoids, 12 lignans, and 20 other components. Among these compounds, three were identified as new including abieta-7,13-diene-12α-methoxy-18-oic acid (1), 7α-methoxy-dehydroabietic acid (2), and 5-hydroxy-6-methyl-7,4′-dimethoxyflavone-8-O-β-D-glucopyranoside (3). These three new compounds (1—3) and all the known terpenoids (4—28) were tested for cytotoxic activities against four tumor cell lines: A549, COLO-25, QGY-25, and THP-1. However, none of them showed a positive effect (IC₅₀>100 μM).

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 58 (12), 1646-1649, 2010

  公益社団法人 日本薬学会

キーワード

• <i>Abies spectabilis</i>
• Pinaceae
• diterpenoid
• flavonoid
• cytotoxic activity

詳細情報

• CRID: 1390001204172368512
• NII論文ID: 130000405697
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.58.1646
• ISSN: 13475223
• ISSN: 00092363
• NDL書誌ID: 10894945
• Web Site: http://id.ndl.go.jp/bib/10894945
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10894945
• Web Site: http://www.jstage.jst.go.jp/article/cpb/58/12/58_12_1646/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可