Regulation of the Violacein Biosynthetic Gene Cluster by Acylhomoserine Lactone-Mediated Quorum Sensing in <i>Chromobacterium violaceum</i> ATCC 12472

  • MOROHOSHI Tomohiro
    Department of Material and Environmental Chemistry, Graduate School of Engineering, Utsunomiya University
  • FUKAMACHI Katsumasa
    Department of Material and Environmental Chemistry, Graduate School of Engineering, Utsunomiya University
  • KATO Masashi
    Department of Material and Environmental Chemistry, Graduate School of Engineering, Utsunomiya University
  • KATO Norihiro
    Department of Advanced Interdisciplinary Sciences, Graduate School of Engineering, Utsunomiya University
  • IKEDA Tsukasa
    Department of Material and Environmental Chemistry, Graduate School of Engineering, Utsunomiya University

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  • Regulation of the Violacein Biosynthetic Gene Cluster by Acylhomoserine Lactone-Mediated Quorum Sensing in Chromobacterium violaceum ATCC 12472

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Chromobacterium violaceum produces the purple pigment violacein by quorum-sensing regulation. 20-bp of the lux box-like sequence was found upstream of vioA in C. violaceum ATCC 12472. CviR received C10-HSL and C6-HSL and activated the transcription of vioA in Escherichia coli. However, in strain ATCC 12472, C6-HSL inhibited both C10-HSL-mediated violacein production and the transcription of vioA.

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