Angioscopic Study of Silent Plaque Disruption in Nonischemic Related Coronary Artery in Patients With Stable Ischemic Heart Disease
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- Wang Zuoyan
- First Department of Internal Medicine, Nippon Medical School
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- Inami Shigenobu
- First Department of Internal Medicine, Nippon Medical School
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- Kirinoki Sonoko
- First Department of Internal Medicine, Nippon Medical School
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- Yamamoto Hideo
- First Department of Internal Medicine, Nippon Medical School
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- Takagi Gen
- First Department of Internal Medicine, Nippon Medical School
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- Aoki Satoshi
- First Department of Internal Medicine, Nippon Medical School
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- Kato Koji
- First Department of Internal Medicine, Nippon Medical School
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- Takano Hitoshi
- First Department of Internal Medicine, Nippon Medical School
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- Asai Kuniya
- First Department of Internal Medicine, Nippon Medical School
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- Yasutake Masahiro
- First Department of Internal Medicine, Nippon Medical School
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- Takano Masamichi
- First Department of Internal Medicine, Nippon Medical School
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- Yamamoto Masatoshi
- Department of Internal Medicine, Chiba Hokusoh Hospital, Nippon Medical School
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- Ohba Takayoshi
- Department of Internal Medicine, Chiba Hokusoh Hospital, Nippon Medical School
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- Mizuno Kyoichi
- First Department of Internal Medicine, Nippon Medical School
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Plaque disruption, which may be associated with some coronary risk factors, plays a key role in the development of acute coronary syndromes and progression of atherosclerosis. However, the clinical profile of asymptomatic plaque disruption in stable ischemic heart disease has not been well evaluated. The aim of the present study was to investigate the frequency and determinants of silent plaque disruption (SPD) in patients with stable ischemic heart disease using coronary angioscopy. Forty-one patients with stable angina or old myocardial infarction (OMI) without any complaints within 3 months were included in the present study. Angioscopy was successfully performed through 49 nonischemic related coronary arteries. The presence of SPD and coronary risk factors were recorded. Silent plaque disruption was found in 12 patients with stable ischemic heart disease (12/41, 29.3%), and the frequency of SPD in nonischemic related coronary arteries was 26.5% (13/49). A significantly higher frequency of SPD was noted in yellow plaques than in white plaques (35.3% versus 6.7%, P = 0.043). Overall, the independent clinical risk factors of SPD in nonischemic related coronary arteries were diabetes mellitus (P = 0.018; OR, 18.8209; 95% CI, 1.6525 to 214.3523) and hypertension (P = 0.0313; OR, 6.6485; 95% CI, 1.1850 to 37.3019). These results suggest silent plaque disruption was commonly observed in nonischemic related coronary arteries in patients with stable ischemic heart disease and its determinants were diabetes mellitus and hypertension.
収録刊行物
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- International Heart Journal
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International Heart Journal 51 (6), 383-387, 2010
一般社団法人 インターナショナル・ハート・ジャーナル刊行会
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詳細情報 詳細情報について
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- CRID
- 1390282680201012992
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- NII論文ID
- 130000410621
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- ISSN
- 13493299
- 13492365
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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