Green Tea Catechins Improve Human Forearm Vascular Function and Have Potent Anti-Inflammatory and Anti-Apoptotic Effects in Smokers

• Oyama Jun-ichi

  Department of Cardiovascular, Respiratory, and Geriatric Medicine, Kyushu University Hospital

• Maeda Toyoki

  Department of Cardiovascular, Respiratory, and Geriatric Medicine, Kyushu University Hospital

• Sasaki Makoto

  Department of Cardiovascular, Respiratory, and Geriatric Medicine, Kyushu University Hospital

• Kozuma Kazuya

  Kao Corporation

• Ochiai Ryuji

  Kao Corporation

• Tokimitsu Ichiro

  Kao Corporation

• Taguchi Sachiyo

  Department of Cardiovascular, Respiratory, and Geriatric Medicine, Kyushu University Hospital

• Higuchi Yoshihiro

  Department of Cardiovascular, Respiratory, and Geriatric Medicine, Kyushu University Hospital

• Makino Naoki

  Department of Cardiovascular, Respiratory, and Geriatric Medicine, Kyushu University Hospital

抄録

Objective Several epidemiological investigations have reported that green tea reduces cardiovascular and cerebral vascular risks. Green tea catechins may improve peripheral endothelial dysfunction in smokers. The purpose of this study was to elucidate the beneficial effect of green tea catechins on the repair of endothelial dysfunction in smokers.<br> Methods Thirty healthy male smokers divided into three groups ingested a green tea beverage containing 0 mg (control group), 80 mg (middle dose group) or 580 mg (high dose group) of green tea catechins (GTC) daily for two weeks, and endothelial-dependent vasodilatation was investigated by measuring forearm blood flow (FBF) response to reactive hyperemia (RH) by venous occlusion strain-gauge plethysmography.<br> Results An acute effect was that the FBF response to RH significantly increased 2 hr after GTC intake in the high dose group. However, no increase was observed in the other groups. The chronic administration of GTC for one or two weeks ameliorated the FBF responses to RH in the high dose group. On the other hand, no significant increase was observed in the FBF responses to RH in the other groups. Moreover, the plasma concentration of 8-OHdG, IL-6, TNF-alpha, and soluble Fas decreased significantly for two weeks in the high dose group, however, the level of IL-1 beta remained unchanged over this period.<br> Conclusion Green tea consumption over short and long periods appears to ameliorate endothelial dysfunction by scavenging free radicals with anti-inflammatory and anti-apoptotic properties in healthy male smokers.<br>

収録刊行物

• Internal Medicine

  Internal Medicine 49 (23), 2553-2559, 2010

  一般社団法人 日本内科学会

キーワード

• green tea catechin
• endothelial dysfunction
• inflammation
• apoptosis
• smoking

詳細情報

• CRID: 1390282679849413120
• NII論文ID: 130000413399
• DOI: 10.2169/internalmedicine.49.4048
• ISSN: 13497235
• ISSN: 09182918
• Web Site: http://www.jstage.jst.go.jp/article/internalmedicine/49/23/49_23_2553/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2011287590
• 本文言語コード: en
• データソース種別:
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