A LONG-TERM REMISSION OF RENAL AMYLOIDOSIS WITH NEPHROTIC SYNDROME AFTER AUTOLOGOUS PERIPHERAL BLOOD STEM-CELL TRANSPLANTATION

• OGAWA KAZUEI

  Department of Cardiology and Hematology, Fukushima Medical University

• IKEDA KAZUHIKO

  Department of Cardiology and Hematology, Fukushima Medical University

• FURUKAWA MIKI

  Department of Cardiology and Hematology, Fukushima Medical University

• HARADA-SHIRADO KAYO

  Department of Cardiology and Hematology, Fukushima Medical University

• MASHIMO YUMIKO

  Department of Cardiology and Hematology, Fukushima Medical University

• TAKAHASHI HIROSHI

  Department of Cardiology and Hematology, Fukushima Medical University

• MATSUMOTO HAYATO

  Department of Cardiology and Hematology, Fukushima Medical University

• KIMURA SATOSHI

  Department of Cardiology and Hematology, Fukushima Medical University

• SHICHISHIMA-NAKAMURA AKIKO

  Department of Cardiology and Hematology, Fukushima Medical University

• OHKAWARA HIROSHI

  Department of Cardiology and Hematology, Fukushima Medical University

• HASHIMOTO YUKO

  Department of Diagnostic Pathology, Fukushima Medical University

• ASAHI KOICHI

  Department of Nephrology, Hypertension, Fukushima Medical University

• NOJI HIDEYOSHI

  Department of Cardiology and Hematology, Fukushima Medical University

• OHTO HITOSHI

  Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University

• TAKEISHI YASUCHIKA

  Department of Cardiology and Hematology, Fukushima Medical University

抄録

Renal amyloidosis is typically characterized by nephrotic syndrome, often with massive proteinuria and refractory peripheral edema. We report the case of a patient with renal amyloidosis associated with nephrotic syndrome who maintained remission for 6 years after undergoing high-dose chemotherapy followed by autologous peripheral blood stem-cell transplantation (auto-PBSCT). The patient was a man aged in his 50s who had developed nephrotic syndrome. Bone marrow aspiration and kidney biopsy determined that the cause of the nephrotic syndrome was renal amyloidosis due to multiple myeloma, and the patient was admitted to our department in July 2003. After one course of chemotherapy, auto-PBSCT was performed in March 2004. Following transplantation, serum M-protein was no longer detectable from March 2005, and the patient achieved complete hematological remission. Subsequently, proteinuria decreased, serum albumin levels normalized, and nephrotic syndrome improved. As of 6 years after transplantation, in March 2010, the patient remained in remission, meaning that auto-PBSCT proved extremely effective as a treatment for renal amyloidosis in this case.

収録刊行物

• 福島医学会

  福島医学会 56 (2), 151-156, 2010

  福島医学会

キーワード

• renal amyloidosis
• nephrotic syndrome
• PBSCT
• multiple myeloma

詳細情報

• CRID: 1390001206305300992
• NII論文ID: 130000419024
• NII書誌ID: AA0065246X
• DOI: 10.5387/fms.56.151
• ISSN: 21854610
• ISSN: 00162590
• Web Site: http://ir.fmu.ac.jp/dspace/handle/123456789/275
• Web Site: https://search.jamas.or.jp/link/ui/2012213125
• 本文言語コード: en
• データソース種別:
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  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可