Physiology: Postnatal development of hypoplastic thymus in semi-lethal dwarf pet/pet males

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  • CHIBA Junko
    Laboratory of Veterinary Physiology, Nippon Veterinary and Life Science University
  • SUZUKI Hiroetsu
    Laboratory of Veterinary Physiology, Nippon Veterinary and Life Science University
  • AOYAMA Hiroaki
    Toxicological Division, The Institute of Environmental Toxicology
  • KATAYAMA Kentaro
    Laboratory of Veterinary Physiology, Nippon Veterinary and Life Science University
  • SUZUKI Katsushi
    Laboratory of Veterinary Physiology, Nippon Veterinary and Life Science University

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  • Postnatal Development of Hypoplastic Thymus in Semi-Lethal Dwarf pet/pet Males

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The petit rat (pet/pet) is a new semi-lethal dwarf mutant with anomalies in the thymus and testes, defects inherited as a single autosomal recessive trait. At birth, these pet/pet rats show low birth weight and extremely small thymuses; at 140 days of age, their thymuses show abnormal involution. In the present study, we examined early postnatal development of hypoplastic pet/pet thymuses. In addition to being hypoplastic at birth, pet/pet thymus growth was almost completely impaired during the early postnatal period. As shown by cellular incorporation of BrdU, the mitotic activity was lower in pet/pet than in normal thymuses, and terminal deoxynucleotidyl transferase dUTP nick end labeling assays showed that apoptosis occurred more often in pet/pet than in normal thymus cells during the first few days after birth. These results indicate that postnatal development of the hypoplastic pet/pet thymus is defective due to the reduced proliferation and increased apoptosis of thymic cells.<br>

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