Virology: Induction of a Th-1-biased IgG subclass response against equine herpesvirus type 1 in horses previously infected with type 4 virus

• BANNAI Hiroshi

  Epizootic Research Center, Equine Research Institute, Japan Racing Association

• TSUJIMURA Koji

  Epizootic Research Center, Equine Research Institute, Japan Racing Association

• KONDO Takashi

  Epizootic Research Center, Equine Research Institute, Japan Racing Association

• NEMOTO Manabu

  Epizootic Research Center, Equine Research Institute, Japan Racing Association

• YAMANAKA Takashi

  Epizootic Research Center, Equine Research Institute, Japan Racing Association

• SUGIURA Takeo

  Epizootic Research Center, Equine Research Institute, Japan Racing Association

• MAEDA Ken

  Department of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University

• MATSUMURA Tomio

  Epizootic Research Center, Equine Research Institute, Japan Racing Association

書誌事項

タイトル別名

• Induction of a Th-1-Biased IgG Subclass Response against Equine Herpesvirus Type 1 in Horses Previously Infected with Type 4 Virus

抄録

An immunoglobulin G (IgG) subclass response against equine herpesvirus type 1 (EHV-1) infection was investigated in horses that were naïve to EHV-1/4 and those that had previously been exposed to EHV-4. The IgG subclass response was determined by an ELISA using EHV-1-specific recombinant gG protein as an antigen. In most horses naïve to EHV-1/4, IgGa, IgGb, and IgG(T) were induced after experimental infection with EHV-1. In contrast, a subclass response dominated by IgGa and IgGb, with no apparent increase in IgG(T), was observed after EHV-1 infection in horses previously infected with EHV-4. Horses naturally infected with EHV-1 in the field showed similar responses. These results indicated that pre-infection with EHV-4 induced a Th-1-biased IgG subclass response against subsequent EHV-1 infection.<br>

収録刊行物

• Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ

  Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ 73 (4), 535-539, 2011

  公益社団法人 日本獣医学会

キーワード

• EHV-1
• EHV-4
• immunoglobulin G
• subclass

詳細情報

• CRID: 1390001206431256448
• NII論文ID: 130000444586
• NII書誌ID: AA10796138
• DOI: 10.1292/jvms.10-0456
• ISSN: 13477439
• ISSN: 09167250
• NDL書誌ID: 11104919
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11104919
• Web Site: http://www.jstage.jst.go.jp/article/jvms/73/4/73_10-0456/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2011213107
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
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