Clinical pathology: Enhanced protection against Heligmosomoides polygyrus in IL-2 receptor β-chain overexpressed transgenic mice with intestinal mastocytosis
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- MORIMOTO Masahiro
- Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University
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- UTSUMIYA Kyoko
- Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University
書誌事項
- タイトル別名
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- Enhanced Protection against Heligmosomoides polygyrus in IL-2 Receptor .BETA.-Chain Overexpressed Transgenic Mice with Intestinal Mastocytosis
- Clinical pathology Enhanced protection against Heligmosomoides polygyrus in IL 2 receptor v chain overexpressed transgenic mice with intestinal mastocytosis
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抄録
IL-2 receptor β-chain overexpressed transgenic (Tg2Rβ) mice lack NK cells, but the development of other lymphocyte subsets and macrophages remained apparently intact. These mice also exhibit intestinal mastocytosis. Helminth infection induces various immune responses, such as mast cells, goblet cells, eosinophils and IgE, mediated by Th2 cytokines. IL-4 is also important in the regulation of resistance and susceptibility to Heligmosomoides polygyrus infection. However, there are contradictory results about the relation between resistance to H. polygyrus and intestinal mastocytosis. The present study showed that Tg2Rβ mice suppressed worm fecundity with mastocytosis without an increase of the levels of goblet cells, eosinophils and IgE compared with control mice. These results clearly indicated that mast cells have the ability for to protect against H. polygyrus infection. However, additional studies are required to evaluate protective effector mechanisms against H. polygyrus.<br>
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 73 (6), 849-851, 2011
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390282681404930560
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- NII論文ID
- 130000445017
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- NII書誌ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 11159987
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可