Preparations of Anthraquinone and Naphthoquinone Derivatives and Their Cytotoxic Effects
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- Cui Xing-Ri
- Faculty of Pharmaceutical Sciences, Josai University
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- Saito Ryota
- Department of Chemistry, Faculty of Sciences, Toho University
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- Kubo Takatsugu
- Faculty of Pharmaceutical Sciences, Josai University
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- Kon Daijiro
- Faculty of Pharmaceutical Sciences, Josai University
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- Hirano Yuich
- Faculty of Pharmaceutical Sciences, Josai University
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- Saito Setsuo
- Faculty of Pharmaceutical Sciences, Josai University
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Chrysophanol and 1,8-di-O-hexylchrysophanol derivatives having nucleic acid bases at position 5 were synthesized. Furthermore, derivatives of menadione substituted at position 11 (type A naphthoquinone derivatives) or methylmenadione substituted at position 7 (type B naphthoquinone derivatives) modified with nucleic acid bases, amines and thiocyano, selenocyano or thioacetyl groups were synthesized. The cytotoxic effects of these derivatives on HCT 116 cells, which poorly express P-glycoprotein (P-gp), and Hep G2 cells, which stably express P-gp, were evaluated by performing 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results were compared with those obtained using 5-fluorouracil (5-FU), which has been used clinically. Several of these derivatives exhibited markedly higher potent cytotoxic effects not only on HCT cancer cells but also Hep G2 cancer cells as compared with 5-FU.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 59 (3), 302-314, 2011
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679149453440
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- NII論文ID
- 130000648937
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 10990452
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
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- 使用不可