Repeated Intracoronary Infusion of Peripheral Blood Stem Cells With G-CSF in Patients With Refractory Ischemic Heart Failure - A Pilot Study -

• Gu Xiang

  Department of Cardiology, Northern People's Hospital, Medical College of Yangzhou University

• Xie Yong

  Department of Cardiology, Northern People's Hospital, Medical College of Yangzhou University

• Gu Jian

  Department of Cardiology, Northern People's Hospital, Medical College of Yangzhou University

• Sun Lei

  Department of Cardiology, Northern People's Hospital, Medical College of Yangzhou University

• He Shenghu

  Department of Cardiology, Northern People's Hospital, Medical College of Yangzhou University

• Xu Rixin

  Department of Cardiology, Northern People's Hospital, Medical College of Yangzhou University

• Duan Junfei

  Department of Cardiology, Northern People's Hospital, Medical College of Yangzhou University

• Zhao Jianye

  Department of Cardiology, Northern People's Hospital, Medical College of Yangzhou University

• Hang Fei

  Department of Cardiology, Northern People's Hospital, Medical College of Yangzhou University

• Xu Houtian

  Department of Cardiology, Northern People's Hospital, Medical College of Yangzhou University

• Li Minghui

  Department of Cardiology, Northern People's Hospital, Medical College of Yangzhou University

• Cao Kejiang

  Department of Cardiology, Jiangsu Institute of Cardiovascular Diseases, Jiangsu Provincial People's Hospital, Nanjing Medical University

• Geng Yongjian

  Center for Cardiovascular Biology & Atherosclerosis Research, Department of Internal Medicine, School of Medicine, University of Texas Health Science Center at Houston & the Laboratory of Heart Failure & Stem Cell Research, Texas Heart Institute

書誌事項

タイトル別名

• – A Pilot Study –

抄録

Background: Recent investigations have suggested the clinical efficacy of granulocyte colony-stimulating factor (G-CSF) infusion alone or in combination with a single dose delivery of peripheral blood stem cells (PBSC) infusion in patients with myocardial infarction (MI) and congestive heart failure (HF). The current study tested the feasibility and effect of repeated intracoronary infusions PBSC and the mobilization of G-CSF in patients with refractory HF after MI. Methods and Results: Patients with recent large MI and a lower left ventricular ejection fraction (LVEF) were enrolled into one of the following 3 groups: Group R (n=15) received repeated intracoronary infusion of PBSC and one-dose of G-CSF; Group S (n=15) received a single infusion of PBSC and a G-CSF dose; and Group C (n=15) received neither PBSC nor a G-CSF dose. Cardiac performance was evaluated by echocardiography and single photon-emission computed tomography (SPECT). All the patients underwent 12-month follow-up. LVEF in Group R (47.00±4.90%) was significantly higher than that in Group S (44.40±3.87%, P<0.01) and Group C (40.80±3.41%, P<0.01). Similarly, the improvement of myocardial perfusion assessed by SPECT in Group R was more than that in Group S (P=0.012) and Group C (P<0.01). Neither death nor new MI occurred. Conclusions: Repeated intracoronary infusions of PBSC plus mobilization of G-CSF might be an optional effective strategy for treating patients with refractory HF after recent large MI. (Circ J 2011; 75: 955-963)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 75 (4), 955-963, 2011

  一般社団法人 日本循環器学会

キーワード

• Granulocyte colony-stimulating factor
• Heart failure
• Heart performance
• Myocardial infarction
• Stem cells

詳細情報

• CRID: 1390001205102109952
• NII論文ID: 10028103561
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-10-0898
• ISSN: 13474820
• ISSN: 13469843
• Web Site: http://www.jstage.jst.go.jp/article/circj/75/4/75_CJ-10-0898/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2011256765
• 本文言語コード: en
• データソース種別:
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  • CiNii Articles
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