Antimicrobial Activity of Gel-Entrapped Catechins toward Oral Microorganisms

• Tamura Muneaki

  Department of Microbiology, Nihon University School of Dentistry Division of Immunology and Pathobiology, Dental Research Center, Nihon University School of Dentistry

• Saito Hideo

  Department of Partial Denture Prosthodontics, Nihon University School of Dentistry

• Kikuchi Kuniyoshi

  Department of Microbiology, Nihon University School of Dentistry Division of Immunology and Pathobiology, Dental Research Center, Nihon University School of Dentistry

• Ishigami Tomohiko

  Department of Partial Denture Prosthodontics, Nihon University School of Dentistry Division of Clinical Research, Dental Research Center, Nihon University School of Dentistry

• Toyama Yoshio

  Medical Nutrition Section, Nutrition Foods Department, Division of Research and Development, Research and Development Center, Meiji Dairies Corporation

• Takami Masao

  Nuritional Evaluation, Product Development Section, Nutritional Marketing Department II, Nutritional Consolidated Marketing Division, Meiji Dairies Corporation

• Ochiai Kuniyasu

  Department of Microbiology, Nihon University School of Dentistry Division of Immunology and Pathobiology, Dental Research Center, Nihon University School of Dentistry

抄録

The oral cavity contains almost half of the commensal bacterial population present in the human body. An increase in the number of these microorganisms may result in systemic diseases such as infective endocarditis and aspiration pneumonia as well as oral infections. It is essential to control the total numbers of these microorganisms in order to suppress disease onset. Thus, we examined the antimicrobial activity of a newly developed gel-entrapped catechin (GEC) preparation against oral microorganisms. The minimum inhibitory concentration (MIC) of GEC was determined based on the relationship between a modified agar diffusion method and a broth microdilution method. GEC inhibited the growth of the Actinomyces, periodontopathic bacteria and Candida strains tested, but did not inhibit the growth of the oral streptococci that are important in the normal oral flora. Commercially available moisture gels containing antimicrobial components showed antimicrobial activity against all of the tested strains. After a series of washes and after a 24-h incubation, GEC retained the antimicrobial activity of the catechins. Catalase prevented GEC-induced growth inhibition of Actinomyces naeslundii and Streptococcus mutans suggesting that hydrogen peroxide may be involved in the antimicrobial activity of catechins. These results suggest that GEC may be useful for controlling oral microorganism populations and reducing the accumulation of dental plaque, thereby helping to prevent periodontal disease and oral candidiasis.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 34 (5), 638-643, 2011

  公益社団法人 日本薬学会

キーワード

• catechin
• anti-microbial activity
• gel
• oral micro-organism
• oral care

詳細情報

• CRID: 1390282679601866112
• NII論文ID: 130000657773
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.34.638
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 11057840
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11057840
• Web Site: http://www.jstage.jst.go.jp/article/bpb/34/5/34_5_638/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2012069537
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可