Chinese Prescription Kangen-karyu Ameliorates the Development of Diabetic Hepatic Damages via Regulating Oxidative Stress and Inflammation in the Liver of db/db Mice

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  • Park Chan Hum
    Institute of Natural Medicine, University of Toyama
  • Yamabe Noriko
    Institute of Natural Medicine, University of Toyama
  • Okamoto Takuya
    Institute of Natural Medicine, University of Toyama Iskra Industry Co., Ltd. School of Pharmaceutical Sciences, Showa University
  • Toriizuka Kazuo
    School of Pharmaceutical Sciences, Showa University
  • Yokozawa Takako
    Institute of Natural Medicine, University of Toyama

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The prevention and treatment of diabetic complications are considered to be the most important for the general care of diabetic patients. We have been conducting pre-clinical animal experiments related to diabetes using Kangen-karyu, a Chinese prescription, to examine its therapeutic potential. In the present study, we further studied the anti-diabetic mechanism of Kangen-karyu, especially on the regulation of hyperglycemia-induced hepatic oxidative stress and inflammation in db/db mice. Kangen-karyu (100 or 200 mg/kg body weight/day, per os (p.o.) was administered every day for 18 weeks to db/db mice, and its effect was compared with vehicle-treated db/db and m/m mice. The administration of Kangen-karyu decreased the elevated serum and hepatic glucose concentration in db/db mice. The elevated expressions of p22phox and Nox-4 proteins (reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunits) were significantly decreased after Kangen-karyu treatments. The oxidative stress-related markers in hepatic tissue (reactive oxygen species, reduced glutathione/oxidized glutathione ratio, and thiobarbituric acid-reactive substance) were also significantly ameliorated by the Kangen-karyu treatments. The db/db mice exhibited the up-regulation of nuclear factor-κBp65, cyclooxygenase-2, and inducible nitric oxide synthase levels in the liver; however, Kangen-karyu treatment significantly reduced those expressions. Taking these into consideration, our findings support the therapeutic evidence for Kangen-karyu ameliorating the development of diabetic hepatic damages via regulating oxidative stress and inflammation.

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