Prophylactic Effects of the Histamine H1 Receptor Antagonist Epinastine and the Dual Thromboxane A2 Receptor and Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells Antagonist Ramatroban on Allergic Rhinitis Model in Mice

• Suzuki Yuh

  Department of Medicinal Pharmacology, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Inoue Toshio

  Department of Pharmacotherapy, Nihon Pharmaceutical University

• Yamamoto Atsuki

  Department of Medicinal Pharmacology, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Sugimoto Yukio

  Department of Medicinal Pharmacology, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

抄録

The prophylactic use of anti-allergic drugs has been proposed to be effective in the treatment of seasonal allergic rhinitis in humans. However, there is little information regarding the prophylactic effect of thromboxane A₂ (TXA₂) receptor antagonist on allergic rhinitis. Recent studies revealed that a TXA₂ receptor antagonist ramatroban could block the prostaglandin D₂ (PGD₂) receptor and chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). In the present study, we investigated the prophylactic effects of the histamine H₁ receptor antagonist epinastine and the TXA₂ receptor antagonist ramatroban and seratrodast on mouse models of allergic rhinitis. Female BALB/c mice were sensitized by an intraperitoneal injection of ovalbumin and alum on days 0, 5, 14 and 21. Seven days later, mice were sensitized by intranasal application of ovalbumin thrice a week. Drugs were administered once a day from day 22. The severity of allergic rhinitis was assessed by determining the extent of 2 nasal allergic symptoms (sneezing and nasal rubbing). Histamine sensitivity and eosinophil infiltration into the nasal mucosa were also determined. Epinastine and ramatroban significantly reduced nasal symptoms and the number of eosinophils in the nasal mucosa. Seratrodast showed no effect on nasal symptoms and eosinophil infiltration into the nasal mucosa. In addition, histamine sensitivity was reduced by epinastine and ramatroban. These results indicate that epinastine and ramatroban induce the prophylactic effect on allergic rhinitis.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 34 (4), 507-510, 2011

  公益社団法人 日本薬学会

キーワード

• rhinitis
• histamine H₁ receptor
• thromboxane A₂ receptor
• epinastine
• ramatroban
• eosinophil

詳細情報

• CRID: 1390282679602303360
• NII論文ID: 130000657839
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.34.507
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 11025316
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11025316
• Web Site: http://www.jstage.jst.go.jp/article/bpb/34/4/34_4_507/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2012000327
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可