The Effect of L-citrulline Ingestion on ECG QT Interval and Autonomic Nervous System Activity
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- Kameda Naoko
- Department of Food and Nutrition Science, Sagami Women's Junior College
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- Okigawa Tatsuya
- Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University
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- Kimura Tetsuya
- Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University
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- Fujibayashi Mami
- Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University
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- Asada Tomoko
- Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University
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- Kinoshita Ryohei
- Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University
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- Baba Sadayuki
- Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University
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- Morita Masahiko
- Healthcare Products Development Center, Kyowa Hakko Bio Co., Ltd.
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- Morishita Koji
- Healthcare Products Development Center, Kyowa Hakko Bio Co., Ltd.
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- Moritani Toshio
- Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University
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抄録
The purpose of this study was to investigate the effect of L-citrulline ingestion on ECG QT interval. To accomplish this purpose, nine male subjects (age: 23.4±0.5 years, weight: 57.7±5.6 kg) participated, who had no history of cardiovascular or respiratory function disorders. Each subject performed two tests (L-citrulline and placebo ingestion) on a separate day. ECG was taken before, and 60 min and 90 min after L-citrulline ingestion. The heart-rate-corrected QT interval (QTc) decreased significantly 60 min (p=0.0004) and 90 min (p=0.011) after L-citrulline ingestion. However, there were no significant changes after placebo ingestion. In addition, the interaction between L-citrulline ingestion and placebo was significant (two-way ANOVA: interaction, p=0.010). Our major finding was that L-citrulline ingestion decreases the QT interval in healthy subjects. This result suggests that transient L-citrulline ingestion may shorten the time required to complete myocardial depolarization and repolarization.
収録刊行物
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- Journal of PHYSIOLOGICAL ANTHROPOLOGY
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Journal of PHYSIOLOGICAL ANTHROPOLOGY 30 (2), 41-45, 2011
日本生理人類学会
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詳細情報 詳細情報について
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- CRID
- 1390001205254036608
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- NII論文ID
- 10028100126
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- NII書誌ID
- AA12113950
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- ISSN
- 18806805
- 18806791
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可