Identification of Dimethylmatairesinol as an Immunoglobulin E-suppressing Component of the Leaves of Cinnamomum camphora

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Abstract

Immunoglobulin E (IgE) plays an important role in allergic diseases. In this study, we found that a methanol extract of leaves of the camphor tree Cinnamomum camphora (C. camphora) reduced the amount of IgE secreted by human myeloma U266 cells. When the methanol extract was fractionated by extraction with organic solvents, the ethyl acetate fraction showed the highest activity. The fraction was further separated into several subfractions by preparative TLC. We identified the component of one of the active subfractions as dimethylmatairesinol. Authentic dimethylmatairesinol exhibited similar activity. Thus, the extract of C. camphora and its components including dimethylmatairesinol have potential as an anti-allergic agent.

Journal

Journal of Health Science  

Journal of Health Science 57(2), 184-187, 2011 

The Pharmaceutical Society of Japan

Codes

  • NII Article ID (NAID) :
    130000663118
  • NII NACSIS-CAT ID (NCID) :
    AA11316464
  • Text Lang :
    EN
  • ISSN :
    1344-9702
  • NDL Article ID :
    11024845
  • NDL Source Classification :
    ZS17(科学技術--医学--衛生学・公衆衛生)
  • NDL Call No. :
    Z54-J464
  • Databases :
    NDL  J-STAGE