Identification of Dimethylmatairesinol as an Immunoglobulin E-suppressing Component of the Leaves of Cinnamomum camphora

• Tanabe Hiroki

  Graduate School of Nutritional and Environmental Sciences, University of Shizuoka

• Fukutomi Ryuuta

  Nisshin Seifun Group Inc.

• Yasui Kensuke

  Health Care Research Center, Nisshin Pharma Inc.

• Kaneko Akihiro

  Health Care Research Center, Nisshin Pharma Inc.

• Imai Shinjiro

  Nisshin Seifun Group Inc.

• Nakayama Tsutomu

  Graduate School of Nutritional and Environmental Sciences, University of Shizuoka

• Isemura Mamoru

  Graduate School of Nutritional and Environmental Sciences, University of Shizuoka

抄録

Immunoglobulin E (IgE) plays an important role in allergic diseases. In this study, we found that a methanol extract of leaves of the camphor tree Cinnamomum camphora (C. camphora) reduced the amount of IgE secreted by human myeloma U266 cells. When the methanol extract was fractionated by extraction with organic solvents, the ethyl acetate fraction showed the highest activity. The fraction was further separated into several subfractions by preparative TLC. We identified the component of one of the active subfractions as dimethylmatairesinol. Authentic dimethylmatairesinol exhibited similar activity. Thus, the extract of C. camphora and its components including dimethylmatairesinol have potential as an anti-allergic agent.

収録刊行物

• ＪＯＵＲＮＡＬ　ＯＦ　ＨＥＡＬＴＨ　ＳＣＩＥＮＣＥ

  ＪＯＵＲＮＡＬ　ＯＦ　ＨＥＡＬＴＨ　ＳＣＩＥＮＣＥ 57 (2), 184-187, 2011

  公益社団法人 日本薬学会

キーワード

• dimethylmatairesinol
• U266
• immunoglobulin E
• camphor tree
• <i>Cinnamomum camphora</i>
• lignan

詳細情報

• CRID: 1390001204497480192
• NII論文ID: 130000663118
• NII書誌ID: AA11316464
• DOI: 10.1248/jhs.57.184
• ISSN: 13475207
• ISSN: 13449702
• NDL書誌ID: 11024845
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11024845
• Web Site: http://www.jstage.jst.go.jp/article/jhs/57/2/57_2_184/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可