ポリ塩化ビニル製品から人工唾液へのフタル酸ジエステルの簡易溶出試験法

DOI 日本農学文献記事索引 Web Site PubMed 被引用文献1件 参考文献24件

書誌事項

タイトル別名
  • A Simple and Reproducible Testing Method for Dialkyl Phthalate Migration from Polyvinyl Chloride Products into Saliva Simulant.
  • Simple and Reproducible Testing Method for Dialkyl Phthalate Migration from Polyvinyl Chloride Products into Saliva Simulant

この論文をさがす

抄録

We describe a method of mechanical agitation to determine rates of dialkyl phthalate migration from polyvinyl chloride (PVC) products into saliva simulant. The method consists of rotary shaking of a sample with 30 mL of saliva simulant (pH 7.0) at 35°C in a 50 mL glass tube at 300 rpm for 15 min, then measuring the amount of dialkyl phthalate in the saliva simulant by HPLC with a UV detector. The migration rates of diisononyl phthalate (DINP), di-2-ethylhexyl phthalate (DEHP) and di-n-butyl phthalate (DBP) from PVC plates containing about 45% (w/w) plasticizer (molded in our laboratory) were identical. However, the migration rates from molded plates containing 13% (w/w) DBP were almost double those of DINP and DEHP at the same ratios. In addition, the amounts of DINP that migrated in vitro after rotary shaking for 15 min were equivalent to those in vivo determined in saliva from volunteers who chewed plates for 60 min. The migration rates of dialkyl phthalates from 11 commercially available toys ranged from 15.6 to 85.2 μg/cm2/h [relative standard deviation (RSD), 3 to 12%].

収録刊行物

  • 食品衛生学雑誌

    食品衛生学雑誌 44 (1), 13-18, 2003

    公益社団法人 日本食品衛生学会

被引用文献 (1)*注記

もっと見る

参考文献 (24)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ