Toxicology: CYP1B1 is polymorphic in cynomolgus and rhesus macaques

• UNO Yasuhiro

  Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories

• MATSUSHITA Akinori

  Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories

• YAMAZAKI Hiroshi

  Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University

書誌事項

タイトル別名

• CYP1B1 is Polymorphic in Cynomolgus and Rhesus Macaques

抄録

Cytochrome P450 (CYP) 1B1 is involved in the metabolic activation of various procarcinogens, and some CYP1B1 genetic variants alter CYP1B1-dependent procarcinogen metabolism. Cynomolgus and rhesus macaques are frequently used in toxicity tests due to their evolutionary closeness to humans. In this study, we attempted to identify CYP1B1 genetic variants in 13 cynomolgus and 4 rhesus macaques. A total of 17 genetic variants were identified, including 8 non-synonymous genetic variants, indicating that, similar to humans, CYP1B1 is polymorphic in macaques. These CYP1B1 genetic variants could be the basis for understanding potential inter-animal differences in macaque CYP1B1-dependent metabolism of promutagens.<br>

収録刊行物

• Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ

  Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ 73 (9), 1229-1231, 2011

  公益社団法人 日本獣医学会

キーワード

• CYP1B1
• cytochrome P450
• genetic variants
• macaque

詳細情報

• CRID: 1390282681406480128
• NII論文ID: 130000677189
• NII書誌ID: AA10796138
• DOI: 10.1292/jvms.11-0137
• ISSN: 13477439
• ISSN: 09167250
• NDL書誌ID: 11251953
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11251953
• Web Site: http://www.jstage.jst.go.jp/article/jvms/73/9/73_11-0137/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2012021670
• 本文言語コード: en
• データソース種別:
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