メトトレキサートの体内動態に及ぼす非ステロイド性抗炎症薬の影響: メタ・アナリシスによる検討

DOI Web Site Web Site 被引用文献3件 参考文献20件

書誌事項

タイトル別名
  • Effect of Nonsteroidal Anti-inflammatory Drugs on Pharmacokinetics of Methotrexate: A Meta-analysis
  • メトトレキサート ノ タイナイ ドウタイ ニ オヨボス ヒステロイドセイ コウエンショウヤク ノ エイキョウ メタ アナリシス ニ ヨル ケントウ

この論文をさがす

抄録

  It is well known that nonsteroidal anti-inflammatory drugs (NSAIDs) affect the pharmacokinetics of methotrexate, but there are several reports showing negative consequences. In this study, we evaluated drug interactions by performing a meta-analysis on published data examining the effect of NSAIDs on pharmacokinetic parameters of methotrexate. The combined standardized mean difference of the maximum blood concentration after oral administration of methotrexate was calculated to be −0.00 (95% confidence interval, −0.30 to 0.30) based on 6 clinical trials, and there was no significant effect of NSAIDs (p=0.9967). However, it is also represented that the NSAIDs significantly increased the area under the blood concentration-time curve of methotrexate (combined standardized mean difference, 0.73; 95% confidence interval, 0.32 to 1.14; p=0.0004; 11 trials). Furthermore, the combined standardized mean differences in total and renal clearance of methotrexate were estimated to be −0.80 (95% confidence interval, −1.41 to −0.18; p=0.0109; 6 trials) and −0.76 (95% confidence interval, −1.40 to −0.11; p=0.0220; 11 trials), respectively, implying that NSAIDs interfere with urinary excretion of methotrexate. In conclusion, the integration of the published reports by these meta-analyses shows that NSAIDs increase blood levels of methotrexate by influencing renal excretion of the antifolate.<br>

収録刊行物

  • 薬学雑誌

    薬学雑誌 131 (5), 853-861, 2011-05-01

    公益社団法人 日本薬学会

被引用文献 (3)*注記

もっと見る

参考文献 (20)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ