A Special focus on the role of α1D-adrenoreceptors in the assessment of renal tubular sodium re-absorptive responses in spontaneously hypertensive rats subjected to high sodium diet

• KAZI Raisa N.

  School of Pharmaceutical Sciences, Universiti Sains Malaysia

• SATTAR Munavvar A.

  School of Pharmaceutical Sciences, Universiti Sains Malaysia

• ABDULLAH Nor A.

  Department of Pharmacology, Faculty of Medicine, Universiti Malaya

• KHAN Md A. Hye

  Department of Pharmacology and Toxicology, Medical College of Wisconsin

• RATHORE Hassaan A.

  School of Pharmaceutical Sciences, Universiti Sains Malaysia

• ABDULLA Mohammed H.

  School of Pharmaceutical Sciences, Universiti Sains Malaysia

• SALMAN Ibrahim M.

  School of Pharmaceutical Sciences, Universiti Sains Malaysia

• JOHNS Edward J.

  Department of Physiology, Aras Windle, University College Cork

書誌事項

タイトル別名

• A Special Focus on the Role of α_1D-Adrenoreceptors in the Assessment of Renal Tubular Sodium Re-absorptive Responses in Spontaneously Hypertensive Rats Subjected to High Sodium Diet
• A Special focus on the role of a1D adrenoreceptors in the assessment of renal tubular sodium re absorptive responses in spontaneously hypertensive rats subjected to high sodium diet

抄録

  α_1D-Adrenoceptors are involved in the genesis/maintenance of hypertension in spontaneously hypertensive rats (SHR). This study aims to investigate the role of α_1D-adrenoceptors in the antinatriuretic and antidiuretic responses in SHR subjected to high sodium (SHRHNa) and normal sodium (SHRNNa) intake for six weeks. Renal inulin clearance study was performed in which the antinatriuretic and antidiuretic responses to phenylephrine were examined in the presence and absence of α_1D-adrenoceptors blocker BMY7378. Data, mean±S.E.M. were subjected to ANOVA with significance at p<0.05. Results show that feeding SHR for six weeks with high salt did not cause any change in blood pressure. SHRHNa had higher (all p<0.05) urine flow rate (UFR), fractional and absolute excretion of sodium (FE_Na and U_NaV) compared to SHRNNa. Phenylephrine infusion produced significant reduction in UFR, FE_Na and U_NaV in both SHRHNa and SHRNNa. The antidiuretic and antinatriuretic responses to phenylephrine in both groups were attenuated in the presence of BMY7378. Moreover, the antidiuretic and antinatriuretic responses to phenylephrine and BMY7378 were independent on any significant changes in renal and glomerular hemodynamics in both groups. Thus we conclude that high sodium intake did not bring any further increase in blood pressure of SHR, however, it results in exaggerated natriuresis and diuresis in SHRHNa. Irrespective of dietary sodium changes, α₁-adrenoceptors are involved in mediating the antinatriuretic and antidiuretic responses to phenylephrine in SHR. Further, high sodium intake did not significantly influence the functionality of α_1D-adrenoceptors in mediating the adrenergically induced antinatriuresis and antidiuresis.<br>

収録刊行物

• 薬学雑誌

  薬学雑誌 131 (3), 431-436, 2011-03-01

  公益社団法人 日本薬学会

キーワード

• α_1D-adrenoceptor
• high sodium
• renal function
• spontaneously hypertensive rat (SHR)

詳細情報

• CRID: 1390282681105349248
• NII論文ID: 130000678908
• NII書誌ID: AN00284903
• DOI: 10.1248/yakushi.131.431
• ISSN: 13475231
• ISSN: 00316903
• NDL書誌ID: 11032276
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11032276
• Web Site: https://www.jstage.jst.go.jp/article/yakushi/131/3/131_3_431/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2011303671
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可