News from the End of the Gut-How the Highly Segmental Pattern of Colonic HCO3- Transport Relates to Absorptive Function and Mucosal Integrity
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- Bachmann Oliver
- Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School
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- Seidler Ursula
- Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School
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A number of transport mechanisms in the colonic epithelium contribute to HCO3− movement across the apical and basolateral membranes, but this ion has been largely regarded as a by-product of the transport functions it is involved in, such as NaCl- or short chain fatty acid (SCFA) absorption. However, emerging data points to several specific roles of HCO3− for colonic epithelial physiology, including pH control in the colonic surface microenvironment, which is important for transport- and immune functions, as well as the secretion and the rheological properties of the mucus gel. Furthermore, recent studies have demonstrated that colonic HCO3− transporters are expressed in a highly segmental as well as species-specific manner. This review summarizes recently gathered information on the functional anatomy of the colon, the roles of HCO3− in the colonic epithelium, colonic mucosal integrity, and the expression and function of HCO3− transporting mechanisms in health and disease.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 34 (6), 794-802, 2011
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204627355008
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- NII論文ID
- 130000738051
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 11095100
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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