Extracellular pH in Restricted Domains as a Gating Signal for Ion Channels Involved in Transepithelial Transport
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- Sandoval Moisés
- Centro de Estudios Científicos (CECS)
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- Burgos Johanna
- Centro de Estudios Científicos (CECS)
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- Sepúlveda Francisco V.
- Centro de Estudios Científicos (CECS) CIN, Centro de Ingeniería de la Innovación asociado al CECS
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- Cid L. Pablo
- Centro de Estudios Científicos (CECS)
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The importance of intracellular pH (pHi) in the regulation of diverse cellular activities ranging from cell proliferation and differentiation to cell cycle, migration and apoptosis has long been recognised. More recently, extracellular pH (pHo), in particular that of relatively inaccessible compartments or domains that occur between cells in tissues, has begun to be acknowledged as a relevant signal in cell regulation. This should not be surprising given the abundant reports highlighting the pHo-dependence of the activity of membrane proteins facing the extracellular space such as receptors, transporters, ion channels and enzymes. Changes in pH affect the ionisation state of proteins through the effect on their titratable groups. There are proteins, however, which respond to pH shifts with conformational changes that are crucial for catalysis or transport activity. In such cases protons act as signalling molecules capable of eliciting fast and localised responses. We provide examples of ion channels that appear fastidiously designed to respond to extracellular pH in a manner that suggests specific functions in transporting epithelia. We shall also present ideas as to how these channels participate in complex transepithelial transport processes and provide preliminary experiments illustrating a new way to gauge pHo in confined spaces of native epithelial tissue.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 34 (6), 803-809, 2011
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679604064256
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- NII論文ID
- 130000738052
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 11095114
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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