How can we classify “mood stabilizers” with different properties?

• Kondo Tsuyoshi

  Department of Neuropsychiatry, Faculty of Medicine, University of the Ryukyus

書誌事項

タイトル別名

• How can we classify “mood stabilizers” with different properties?

抄録

Mood stabilizers have been conventionally defined as drugs possessing efficacy in both acute and maintenance therapy for any polarity of bipolar disorder. Only lithium has been regarded as the gold standard mood stabilizer, fulfilling all of these conditions. Recently, evidence for the comprehensive mood-stabilizing effects of second-generation antipsychotics such as quetiapine and olanzapine has been found, although their safety in long-term use is still of great concern. Antiepileptic drugs do not appear to be ideal mood stabilizers because of selective effectiveness on a particular polarity -- for example, valproate and carbamazepine are predominantly antimanic, and lamotrigine is predominantly antidepressive. However, the mood-stabilizing effects of combinations of these drugs may be equivalent or even superior to that of lithium alone, especially in pathophysiologies less responsive to lithium, such as dysphoric mania, mixed features and rapid cycling.

収録刊行物

• Clinical Neuropsychopharmacology and Therapeutics

  Clinical Neuropsychopharmacology and Therapeutics 2 (0), 12-23, 2011

  日本臨床精神神経薬理学会

キーワード

• mood stabilizers
• bipolar disorders
• polarity
• acute effect
• relapse prevention

詳細情報

• CRID: 1390001205336725120
• NII論文ID: 130000743683
• DOI: 10.5234/cnpt.2.12
• ISSN: 18848826
• Web Site: https://search.jamas.or.jp/link/ui/2013137080
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可