７％炭酸水素ナトリウム液添加によるアクラルビシン・リピオドール溶液を用いたｏｉｌ‐ｃｈｅｍｏ‐ｅｍｂｏｌｉｚａｔｉｏｎの基礎的検討

• 寺嶋 吉保

  徳島大学医学部第一外科学教室

• 国友 一史

  徳島大学医学部第一外科学教室

• 古味 信彦

  徳島大学医学部第一外科学教室

書誌事項

タイトル別名

• Aclalubicin/Lipiodol solution(ACR/LPD)with 7% sodium bicarbonate as a material for oil-chemo-embolization:A fundamental study.
• A fundamental study
•  

抄録

Water soluble aclalubicin hydrochloride(ACR, Aclacinone^®, Yamanouchi Pharmaceutical Comp. Japan) was dissolued into Lipiodol Ultra-Fluid^®(Kodama Co. Ltd. Japan) with an addition of an equivalent amount of 7% sodium bicarbonate (Meylon^®, Otuska Pharm. Co. Ltd. Japan). A maximum concentration of ACR in LPD reached to approximately 20 mg/ml. Release of ACR from ACR/LPD solution was documented for more than 6 weeks period. Intraarterial infusion of ACR/LPD (1.5 mg/0.1 ml/kg) reduced tumor growth significantly(P<0.01-0.05)in rabbit VX-2 hepatoma model comparing to groups they received ACR/H₂ O solution (ACR 1 mg/kg, 1.5 mg/kg), LPD alone(0.1 ml/kg), and ACR/LPD (1.0 mg/0.1 mg/kg). These results suggest that the ACR/LPD solution with 7% sodium bicarbonate may be an active agent for intraarterial targeting chemotherapy which has delayed releasing of ACR.

収録刊行物

• Ｄｒｕｇ　Ｄｅｌｉｖｅｒｙ　Ｓｙｓｔｅｍ

  Ｄｒｕｇ　Ｄｅｌｉｖｅｒｙ　Ｓｙｓｔｅｍ 6 (3), 177-181, 1991

  日本DDS学会

キーワード

• lipiodol
• targeting chemotherapy
• oil-climo-embolization
• aclarubicin/lipiodol solusion
• 7% sodium bicarbonate

詳細情報

• CRID: 1390282679618807168
• NII論文ID: 130000747475
• DOI: 10.2745/dds.6.177
• ISSN: 18812732
• ISSN: 09135006
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可