Inhibition of restriction enzymes EcoR1, BamH1 and Hind3 by phenethylphenylphthalimides derived from thalidomide

• Motoshima Kazunori

  Institute of Molecular & Cellular Biosciences, The University of Tokyo

• Ishikawa Minoru

  Institute of Molecular & Cellular Biosciences, The University of Tokyo

• Hashimoto Yuichi

  Institute of Molecular & Cellular Biosciences, The University of Tokyo

• Sugita Kazuyuki

  Institute of Molecular & Cellular Biosciences, The University of Tokyo

書誌事項

タイトル別名

• Inhibition of Restriction Enzymes EcoRI, BamHI and HindIII by Phenethylphenylphthalimides Derived from Thalidomide

抄録

We discovered inhibitors of the restriction enzymes EcoRI, BamHI and HindIII by screening our library of compounds with a phenethylphenylphthalimide skeleton, based on α-glucosidase inhibitors and liver X receptor antagonists derived from thalidomide. Structural development afforded the potent restriction enzyme inhibitors 25 and 26.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 59 (7), 880-884, 2011

  公益社団法人 日本薬学会

キーワード

• restriction enzyme
• endonuclease
• enzyme inhibitor
• phthalimide

詳細情報

• CRID: 1390001204172266240
• NII論文ID: 130000748024
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.59.880
• ISSN: 13475223
• ISSN: 00092363
• NDL書誌ID: 11132169
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11132169
• Web Site: http://www.jstage.jst.go.jp/article/cpb/59/7/59_7_880/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2012169226
• 本文言語コード: en
• データソース種別:
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