Isoproterenolおよびpapaverineの鎮痙作用におよぼす外液Na除去の影響,とくにCaとの関連(ラット摘出直腸での実験)

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  • Influence of removal of Na from bath solution on the antispasmodic actions of isoproterenol and papaverine in relation to Ca (Experiments on isolated rat rectum)
  • Isoproterenol オヨビ papaverine ノ チンケイ サヨウ

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Influence of the Na removal from bath solution on the antispasmodic actions of isoproterenol and papaverive against the phasic contractions by K and acetylcholine were investigated in relation to the mobilization of Ca in isolated rectal strip from the rat. Effect of the Na removal on the uptake of intracellular Ca into storage sites was also examined. The Na removal attenuated the inhibitory actions of isoproterenol and papaverine on the release of Ca, whereas the Na removal did not affect the inhibitory action of isoproterenol on Ca influx and that of papaverine on the response of the muscle contractile elements. Furthermore, the Na removal inhibited the uptake of intracellular Ca into storage sites. Thus, it is suggested that isoproterenol and papaverine may generate the inhibitory action on the release of Ca by accelerating Ca uptake into storage sites, therefore the antispasmodic actions of these agents are depressed by the deprivation of Na from the bath solution which attenuates the Ca uptake.

収録刊行物

  • 日本薬理学雑誌

    日本薬理学雑誌 72 (1-2), 177-184, 1976

    公益社団法人 日本薬理学会

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