EnfluranとHalothaneの薬理作用比較

DOI Web Site PubMed

書誌事項

タイトル別名
  • Pharmacological comparison between enflurane and halothane
  • Enflurane ト Halothane ノ ヤクリ サヨウ ヒカク

この論文をさがす

抄録

General pharmacological properties of enflurane (E) and halothane (H) were investigated. Maximum bloodconcentrations of both drugs reached 30min after inhalation. E showed lower maximum blood concentration, initial velocity of uptake and shorter half life than H. Neither drug had any effect on neuromuscular junction, but E increased N-M effect of succinylcholine. Both drugs decreased tension of uterine and intestine muscles. Poly- and monosynaptic reflexes were inhibited more by H. ED50's of E and H for righting reflex were 1.25 and 1.40%, respectively. Tonic and clonic convulsions and death induced by electric shock were inhibited more by E. Almost equal anticonvulsive potency was observed for chemoshocks. Death due to electric and chemoshock was remarkably inhibited by both drugs. Spontaneous EEG was altered in a different manner, although flattened with spikes at 4% concentration of both drugs. E altered rhythmicity of recruiting response and both drugs inhibited this response. H inhibited more remarkably the augmenting response and E inhibited the arousal response. E increased negative potentials of the primary response evoked by sensory stimulation, while H decreased these potentials. Both drugs completely inhibited the secondary response.

収録刊行物

  • 日本薬理学雑誌

    日本薬理学雑誌 72 (1-2), 211-227, 1976

    公益社団法人 日本薬理学会

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ