β‐フェネチルアミン誘導体の中枢作用　ＶＩＩ　　チラミン脳内投与によるマウス脳内モノアミンの変動

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  • Central action of β-phenylethylamine derivatives. (7) Effect of intracerebral administration of tyramine on brain monoamine in mice.
  • ベータ Phenylethylamine ユウドウタイ ノ チュウスウ サヨウ

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1) Tyramine (Ty), octopamine, dopamine (DA), noradrenaline (NA) and 5-hydroxytryptamine (5-HT) were separated on a phosphorylated-cellulose column (1 × 32cm; 26m1). 2) When Ty was qualitatively analyzed by native fluorescence, Ty reached to peak 30 min after i. c. administration of Ty and disappeared 120 min after administration. 3) 30min after Ty (160 μg, i. c.) the maximum increase of DA was observed. Though DA was maintained at the significant increase level as compared with the saline-treated group, there was no significant difference in the level 120 min later. 4) 30 ?? 60 min after Ty (160 μg, i. c.), NA and 5-HT decreased significantly compared with the saline-treated group. 120 min after Ty, both amines recovered to the normal levels. 5) 30 min after Ty, the increase in DA was dependent in proportion to doses of Ty, and the decrease in NA and 5-HT was also in parallel. 6) 30 min after the pretreatment of isocarboxazide, injection of Ty produced a significant increase in the DA level as compared with the non-pretreated group and the decrease of NA level compared with control (MAOI + saline). Although the injection of Ty only reduced the 5-HT level, the administration of Ty produced an increase in the 5-HT level in mice pretreated with MAGI.

収録刊行物

  • 日本薬理学雑誌

    日本薬理学雑誌 72 (4), 371-379, 1976

    公益社団法人 日本薬理学会

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