新しい抗うつ剤ロプラミンの行動薬理学的研究

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タイトル別名
  • Behavioral pharmacology of lopramine
  • アタラシイ コウウツザイ Lopramine ノ コウドウ ヤクリガクテキ ケ

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抄録

The behavioral effects of lopramine [N-methyl-N-(4-chlorobenzoyl-methyl)-3-(10, 11-dihydro-5H-dibenz (b, f) azepin-5-yl)propylamine hydrochloride] were investigated in mice and rats and compared with those of amitriptyline and imipramine. Lopramine inhibited reserpine hypothermia and haloperidol catalepsy in mice and tetrabenazine ptosis in rats. In addition, the drug potentiated the effects of methamphetamine, and DOPA or apomorphine-induced stereotypy in mice, whereas it suppressed muricide of the rat induced by either olfactory bulbectomy or Δ9-tetrahydrocannabinol, similar to the responses seen with imipramine and amitriptyline. On the other hand, lopramine increased spontaneous motor activity and markedly potentiated methamphetamine hyperactivity. In contrast to imipramine and amitriptyline, lopramine failed to counteract both the lethal effect of physostigmine and oxotremorine tremor in mice, indicating that the drug had no central anticholinergic effect. Lopramine, even at such a large dose as 5, 000 mg/kg p.o., caused neither impairment of coordinated motor activity nor muscle relaxation. It is concluded that lopramine is a new type of tricyclic antidepressant with extremely low toxicity and without central anticholinergic action.

収録刊行物

  • 日本薬理学雑誌

    日本薬理学雑誌 72 (5), 585-607, 1976

    公益社団法人 日本薬理学会

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