Inhibitory effect of 2-(2-fluoro-4-biphenylyl) propionic acid (Flurbiprofen) on prostaglandin synthesis
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- MASUMOTO Shozo
- Research Laboratory, Kakenyaku-kako Co. Ltd
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- MASUDA Chiharu
- Research Laboratory, Kakenyaku-kako Co. Ltd
Bibliographic Information
- Other Title
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- 2‐(2‐フルオロ‐4‐ビフェニリル)プロピオン酸(フルルビプロフェン)のプロスタグランジン合成阻害作用
- 2 2 Fluoro 4 biphenylyl propionic acid
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Abstract
Inhibitory effects cf 2-(2-fluoro-4-biphenylyl) propionic acid (Flurbiprofen, FP-70) on prostaglandin (PG) synthesis and PG activity were investigated both in vivo and in vitro. FP-70 at 0.64 μM showed 50% inhibitory effect on PG synthesis from arachidonic acid in cell-free homogenate of guinea pig lung. PGE2 and PGF2α in the sample of lung homogenate incubated with arachidonic acid were separated by thin-layer chromatography in solvent AI system. FP-70 inhibited strongly both synthesis of PGE2 and PGF2α, at 3 μM, but inhibited more extensively the synthesis of PGE2 than that of PGF2α at 0.3 μM. FP-70 at 1 mg/kg, p.o. inhibited mostly arachidonic acid potentiation of carrageenin-induced edema in the rat paw, but did not inhibit PGE2 potentiation of carrageenin-induced edema. FP-70 also did not inhibit the contraction of rat stomach strip induced by PGE2. From the above and previously5) reported results, FP-70 proved to inhibit PG synthesis but not PG activity. It is suggested that the potent anti-inflammatory action of FP-70 is the result of inhibition of PG synthesis.
Journal
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- Folia Pharmacologica Japonica
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Folia Pharmacologica Japonica 72 (8), 1025-1031, 1976
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390282679249005824
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- NII Article ID
- 130000758607
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- NII Book ID
- AN00198335
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- COI
- 1:CAS:528:DyaE1cXis10%3D
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- ISSN
- 13478397
- 00155691
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- NDL BIB ID
- 1798731
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- PubMed
- 1035562
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed